ArticlePloS one2021
Long-term outcome of prolonged critical illness: A multicentered study in North Brisbane, Australia.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Long-term survival of patients with persistent critical illness in Australia and New Zealand; a retrospective registry-based cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Hypoxia-Inducible Factor 1-alpha (HIF1α), Nicotinamide Adenine Dinucleotide (NAD+, NADH), and Nitric Oxide (NO) interplay in critically ill patients, with implications for patient safety and targeted therapies: a review.Patient safety in surgery · 2025Review
- Association between enteral carboxymethyllysine intake and daily glycemic variability in critically ill adults: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Characteristics Associated with Length of Stay in Intensive Care Unit for Cancer Patients in China: A Nationwide Retrospective Cohort Study.Journal of multidisciplinary healthcare · 2025Article
- Risk factors and economic impact of long-term nursing care after major trauma.Frontiers in public health · 2025Article
- Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice.Critical care (London, England) · 2024Article
- ICU-acquired hypernatremia: Prevalence, patient characteristics, trajectory, risk factors, and outcomes.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Point-of-care creatinine vs. central laboratory creatinine in the critically ill.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Passive Movements Do not Appear to Prevent or Reduce Joint Stiffness in Medium to Long-Stay ICU Patients: A Randomized, Controlled, Within-Participant Trial.Critical care explorations · 2023Article
- Factors Affecting the Length of Stay in the Intensive Care Unit among Adults in Saudi Arabia: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Impact of frailty on persistent critical illness: a population-based cohort study.Intensive care medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough critical illness is usually of high acuity and short duration, some patients require prolonged management in intensive care units (ICU) and suffer long-term morbidity and mortality.
objectiveTo describe the long-term survival and examine determinants of death among patients with prolonged ICU admission.
methodsA retrospective cohort of adult Queensland residents admitted to ICUs for 14 days or longer in North Brisbane, Australia was assembled. Comorbid illnesses were classified using the Charlson definitions and all cause case fatality established using statewide vital statistics.
resultsDuring the study a total of 28,742 adult Queensland residents had first admissions to participating ICUs of which 1,157 (4.0%) had prolonged admissions for two weeks or longer. Patients with prolonged admissions included 645 (55.8%), 243 (21.0%), and 269 (23.3%) with ICU lengths of stay lasting 14-20, 21-27, and ≥28 days, respectively. Although the severity of illness at admission did not vary, pre-existing comorbid illnesses including myocardial infarction, congestive heart failure, kidney disease, and peptic ulcer disease were more frequent whereas cancer, cerebrovascular accidents, and plegia were less frequently observed among patients with increasing ICU lengths of stay lasting 14-20, 21-27, and ≥28 days. The ICU, hospital, 90-day, and one-year all cause case-fatality rates were 12.7%, 18.5%, 20.2%, and 24.9%, respectively, and were not different according to duration of ICU stay. The median duration of observation was 1,037 (interquartile range, 214-1888) days. Although comorbidity, age, and admitting diagnosis were significant, neither ICU duration of stay nor severity of illness at admission were associated with overall survival outcome in a multivariable Cox regression model.
conclusionsMost patients with prolonged stays in our ICUs are alive at one year post-admission. Older age and previous comorbidities, but not severity of illness or duration of ICU stay, are associated with adverse long-term mortality outcome.
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