ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021
Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Running-based rehabilitation does not improve muscle function after volumetric muscle loss despite improving hindlimb weight-bearing asymmetry in mice.Experimental physiology · 2026Article
- Cellular signaling within aged skeletal muscle reveals a dysregulated stress-induced remodeling response following volumetric muscle loss in female mice.Physiological reports · 2026Article
- Re-innervation of neuromuscular junctions by a conductive polypyrrole/silk fibroin/GelMA hydrogel facilitated functional skeletal muscle regeneration following volumetric muscle loss.Journal of orthopaedic translation · 2026Article
- Juvenile vs. adult skeletal muscle transplants in the treatment of volumetric muscle loss injury.Stem cell research & therapy · 2025Article
- Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury.The Journal of physiology · 2025Article
- Retrospective transcriptomic analysis indicates temporal dysregulation of mitochondrial genes and metabolic pathways after volumetric muscle loss injury.Physiological reports · 2025Article
- Biomaterial-Based Regenerative Strategies for Volumetric Muscle Loss: Challenges and Solutions.Advances in wound care · 2025Review
- Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of volumetric muscle loss.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Cell-scale porosity minimizes foreign body reaction and promotes innervated myofiber formation after volumetric muscle loss.NPJ Regenerative medicine · 2025Article
- Biosponge-Encased Placental Stem Cells for Volumetric Muscle Loss Repair.Advances in wound care · 2025Article
- Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025Review
- Differential evaluation of neuromuscular injuries to understand re-innervation at the neuromuscular junction.Experimental neurology · 2024Article
- Tissue Engineered 3D Constructs for Volumetric Muscle Loss.Annals of biomedical engineering · 2024Review
- Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction.npj metabolic health and disease · 2024Article
- Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Aligned Collagen Sponges with Tunable Pore Size for Skeletal Muscle Tissue Regeneration.Journal of functional biomaterials · 2023Article
- Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury.Experimental physiology · 2023Article
- Response of terminal Schwann cells following volumetric muscle loss injury.Experimental neurology · 2023Article
- Exploring skeletal muscle tolerance and whole-body metabolic effects of FDA-approved drugs in a volumetric muscle loss model.Physiological reports · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volumetric muscle loss (VML) is the traumatic loss of muscle tissue that results in long-term functional impairments. Despite the loss of myofibers, there remains an unexplained significant decline in muscle function. VML injury likely extends beyond the defect area, causing negative secondary outcomes to the neuromuscular system, including the neuromuscular junctions (NMJs), yet the extent to which VML induces denervation is unclear. This study systematically examined NMJs surrounding the VML injury, hypothesizing that the sequela of VML includes denervation. The VML injury removed ∼20% of the tibialis anterior (TA) muscle in adult male inbred Lewis rats (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.