Evidence map›Paper›PMID 33830777›Full record

ArticleJournal of proteome research2021

Untargeted Stable Isotope Probing of the Gut Microbiota Metabolome Using

Pan Deng, Taylor Valentino, Michael D Flythe, Hunter N B Moseley, Jacqueline R Leachman, Andrew J Morris, Bernhard Hennig

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. UncoveringGut microbes · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Microbiome · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pan DengSuperfund Research Center, University of Kentucky, Lexington 40536, Kentucky, United States.ORCID 0000-0003-2974-7389
Taylor ValentinoDepartment of Physiology, University of Kentucky, Lexington 40536, Kentucky, United States.
Michael D FlytheDepartment of Animal and Food Sciences, University of Kentucky, Lexington 40536, Kentucky, United States.
Hunter N B MoseleySuperfund Research Center, University of Kentucky, Lexington 40536, Kentucky, United States.
Jacqueline R LeachmanDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington 40536, Kentucky, United States.
Andrew J MorrisSuperfund Research Center, University of Kentucky, Lexington 40536, Kentucky, United States.
Bernhard HennigSuperfund Research Center, University of Kentucky, Lexington 40536, Kentucky, United States.
University of Kentucky · USUnited States Department of Agriculture · US

Funding

Vascular Mechanisms of PCB-Induced Brain MetastasesP42ES007380 · NIEHS · UNIVERSITY OF KENTUCKY · PI PEARSON, KEVIN JOSEPH · 1997 to 2024
$47.8M
Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
Triple Quadrupole Mass Spectrometer SystemS10OD021753 · OD · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2017 to 2017
$352k
BLRD VA I01 BX005637NIEHS NIH HHS P42 ES007380NIGMS NIH HHS P30 GM127211NIH HHS S10 OD021753
6 · The paper itself

Abstract

The gut microbiome generates numerous metabolites that exert local effects and enter the circulation to affect the functions of many organs. Despite extensive sequencing-based characterization of the gut microbiome, there remains a lack of understanding of microbial metabolism. Here, we developed an untargeted stable isotope-resolved metabolomics (SIRM) approach for the holistic study of gut microbial metabolites. Viable microbial cells were extracted from fresh mice feces and incubated anaerobically with

Indexed as

Gastrointestinal MicrobiomeMetabolomeAnimalsDietary FiberFecesIsotopesMetabolomicsMiceDietary FiberIsotopesdietary fiberinulinmetabolitemetabolomicsmicrobiomestable isotope

Identifiers

PMID33830777
PMCPMC8784920
OpenAlexW3150341331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.