ArticleJournal of the American Chemical Society2021
Cross-Selective Aza-Pinacol Coupling via Atom Transfer Catalysis.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Dynamic "Deactivation" mechanism enables epoxides ring-opening to prepare α-substituted alcohols.Nature communications · 2026Article
- Synthesis of Cyclopropene-Modified Fatty Acids Allows Single-Cell Quantification of Uptake by Immune Cells.Angewandte Chemie (International ed. in English) · 2026Article
- Ketones to ketyls by radical relocation.Nature chemistry · 2026Article
- A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.Science advances · 2026Article
- Aldehyde-Olefin Couplings by Photoinduced Reduction of Electron-Deficient Olefins with Hantzsch Ester Anions.Angewandte Chemie (International ed. in English) · 2026Article
- Femtosecond-to-Second Time-Resolved Spectroscopy Brings Unparalleled Insight Into the Life Cycle of the Versatile Manganese Photocatalyst [MnJournal of the American Chemical Society · 2026Article
- Evolution of manganese low-energy photoredox catalysis from high-energy visible light photocatalysis.Nature communications · 2026Article
- Innovative On-Resin and in Solution Peptidomimetics Synthesis via Metal-Free Photocatalytic Approach.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Catalytic Aldehyde-Alkyne Couplings Triggered by Ketyl Radicals.Organic letters · 2024Article
- Radical Polarity.Journal of the American Chemical Society · 2024Article
- Aldehyde-Olefin Couplings Via Sulfoxylate-Mediated Oxidative Generation of Ketyl Radical Anions.Journal of the American Chemical Society · 2024Article
- Cyclopropanation with Non-Stabilized Carbenes via Ketyl Radicals.Journal of the American Chemical Society · 2024Article
- Mild ketyl radical generation and coupling with alkynes enabled by Cr catalysis: stereoselective access toChemical science · 2024Article
- Article
- Carbonyl cross-metathesis via deoxygenative gem-di-metal catalysis.Nature chemistry · 2024Article
- Facile synthesis of 1,2-aminoalcoholsChemical science · 2023Article
- Ketyl Radical Coupling Enabled by Polycyclic Aromatic Hydrocarbon Electrophotocatalysts.Journal of the American Chemical Society · 2023Article
- Carbene reactivity from alkyl and aryl aldehydes.Science (New York, N.Y.) · 2022Article
- Catalytic defluorinative ketyl-olefin coupling by halogen-atom transfer.Chemical science · 2022Article
- Site-selective coupling of remote C(spChemical science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A cross-selective aza-pinacol coupling of aldehydes and imines has been developed to afford valuable β-amino alcohols. This strategy enables chemoselective conversion of aliphatic aldehydes to ketyl radicals, in the presence of more easily reduced imines and other functional groups. Upon carbonyl-specific activation by AcI, a photoinitiated Mn catalyst selectively reduces the resulting α-oxy iodide by an atom transfer mechanism. The ensuing ketyl radical selectively couples to imines, precluding homodimerization by a classical reductive approach. In this first example of reductive, ketyl coupling by atom transfer catalysis, Zn serves as a terminal reductant to facilitate Mn catalyst turnover. This new strategy also enables ketyl radical couplings to alkenes, alkynes, aldehydes, propellanes, and chiral imines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.