Evidence map›Paper›PMID 33830733›Full record

ArticleACS applied materials & interfaces2021

Shear-Resistant, Biological Tethering of Nanostimulators for Enhanced Therapeutic Cell Paracrine Factor Secretion.

Yu-Tong Hong, Jye Yng Teo, Hojeong Jeon, Hyunjoon Kong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Modeling of spatiotemporal dynamics of ligand-coated particle flow in targeted drug delivery processes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Yu-Tong HongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Jye Yng TeoInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore.
Hojeong JeonCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
Hyunjoon KongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID http://orcid.org/0000-0003-4680-2968
University of Illinois Urbana-Champaign · USInstitute of Bioengineering and Nanotechnology · SGKorea University · KR

Funding

Stochastic Modeling of Tissue Injury, Edema and Targeted Drug Delivery R01GM135921 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MASUD, ARIF · 2019 to 2021
$570k
Development of a Liposomal Nanostimulator to Improve Stem Cell-Based Revascularization TherapiesR21HL131469 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2016 to 2017
$428k
Nano-sized Cell Guidance System for Ischemic Tissue RepairR21HL097314 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2009 to 2010
$410k
NHLBI NIH HHS R21 HL097314NHLBI NIH HHS R21 HL131469NIGMS NIH HHS R01 GM135921
6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) secreting multiple growth factors and immunomodulatory cytokines are promising for regenerative medicine. To further enhance their secretory activity, efforts have emerged to tether nanosized carriers of secretory stimuli, named nanostimulators, to the MSC surface by forming nonchemical bonds. Despite some successes, there is a great need to improve the retention of nanostimulators during transport through a syringe needle, where high shear stress exerted on the cell surface separates them. To this end, we hypothesize that poly(lactic-

Indexed as

Shear StrengthBiocompatible MaterialsEndothelial CellsHyaluronan ReceptorsHyaluronic AcidInjectionsNanotechnologyOligopeptidesParacrine CommunicationPolylactic Acid-Polyglycolic Acid CopolymerStress, Mechanicalarginyl-glycyl-aspartic acidBiocompatible MaterialsHyaluronan ReceptorsHyaluronic AcidOligopeptidesPolylactic Acid-Polyglycolic Acid Copolymerflow-induced shear stresshyaluronic acidmesenchymal stromal cellspoly(lactic-co-glycolic acid)RGD peptidesurface tethering

Identifiers

PMID33830733
PMCPMC10440850
OpenAlexW3145527972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.