Evidence map›Paper›PMID 33830664›Full record

ArticleFEBS open bio2021

Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.

Shuang Yao, Fan Zheng, Yang Yu, Yuxia Zhan, Ning Xu, Guanghua Luo, Lu Zheng

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07174687 (Efficacy of Dapagliflozin in the Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07174687 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Dapagliflozin in the Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2028Enrolled70ConditionsRetinal Degeneration, Retinal Diseases, Eye Diseases, Geographic AtrophyArmsDapagliflozin, Matching Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shuang YaoClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.ORCID 0000-0003-3686-5404
Fan ZhengXiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Yang YuClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Yuxia ZhanClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Ning XuSection of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lund University, Sweden.
Guanghua LuoClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.ORCID 0000-0001-8339-2828
Lu ZhengClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.ORCID 0000-0002-5563-4348
Soochow University · CNHubei University of Arts and Science · CNLund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein M (ApoM) exhibits various anti-atherosclerotic functions as a component of high-density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR-BI) is a classic HDL receptor that mediates selective cholesterol uptake and enhances the efflux of cellular cholesterol to HDL. However, the effect of ApoM on cholesterol transport in macrophages remains unclear. In this study, we identified for the first time that ApoM is expressed in mouse macrophages and is involved in cholesterol uptake, similar to SR-BI. NBD-cholesterol uptake and efflux in cells were characterized using fluorescence spectrophotometry. The uptake ratios of cholesterol by macrophages from ApoM

Indexed as

AnimalsApolipoproteins MBiological TransportCholesterolMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutApolipoproteins MApoM protein, mouseCholesterolapolipoprotein Matherosclerosischolesterolhigh-density lipoproteinScavenger receptor class B type I

Identifiers

PMID33830664
PMCPMC8167864
OpenAlexW3140651440

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.