Evidence map›Paper›PMID 33830413›Full record

ArticleMetabolic brain disease2021

Pre-micro RNA polymorphism detection in small versus large vessel disease in stroke Egyptian patients.

Ekrami A Hassan, Hala M El-Khawas, Afify H, Alaa A Alzahaby, Mustafa M M Elbakry, Hossam M Shokri

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Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ekrami A HassanBiochemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.
Hala M El-KhawasNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Afify HNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Alaa A AlzahabyNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mustafa M M ElbakryBiochemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt. mustafaelbakry@sci.asu.edu.eg.ORCID http://orcid.org/0000-0003-3416-7063
Hossam M ShokriNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80-85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluate the influence of three common single nucleotide polymorphisms in pre-miRNAs (hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444) on individual susceptibility to the risk of ischemic stroke subtypes in Egyptian population with 117 ischemic stroke patients. Results showed that hsa-miR-146a/rs2910164 was significantly associated with the risk of small vessel disease stroke in Egyptian population with no significant association between hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444 with the risk of ischemic stroke. Therefore, it can be concluded that miR-146a/rs2910164 polymorphism is involved in the vulnerability to small vessel disease ischemic stroke risk in Egyptian population.

Indexed as

AgedCerebral Small Vessel DiseasesCerebrovascular DisordersCross-Sectional StudiesEchocardiographyEgyptElectrocardiographyFemaleGenetic Predisposition to DiseaseHumansIschemic StrokeMagnetic Resonance ImagingMaleMicroRNAsMiddle AgedPolymorphism, GeneticMicroRNAsMIRN146 microRNA, humanMIRN499 microRNA, humanIschemic strokemicroRNAPolymorphismSmall vessel disease stroke

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PMID33830413
OpenAlexW3148421775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.