ArticleJournal of bone and mineral metabolism2021
Association of hemoglobin level with fracture: a nationwide cohort study.
Article in Journal of bone and mineral metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Gout and allopurinol adherence in newly diagnosed patients and the risk of fractures: a nationwide cohort study.Clinical rheumatology · 2026Article
- Increased fracture risk associated with iron-deficiency anemia: a population-based propensity score matched cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- MMPro-HIP: multimodal progressive fusion model for elderly HIP fracture risk prediction.Frontiers in medicine · 2026Article
- Duration, dose, and responsiveness to erythropoiesis-stimulating agents and risk of osteoporotic fracture among patients with chronic kidney disease in Hong Kong: a nested case-control study.EClinicalMedicine · 2025Article
- Sex differences in hemoglobin levels and five-year refracture risk in patients with osteoporotic fractures: a retrospective cohort analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Moderate to severe anemia at admission increases the risk of complications in patients over 60 years with hip fracture.BMC geriatrics · 2024Article
- Hemoglobin Levels Improve Fracture Risk Prediction in Addition to FRAX Clinical Risk Factors and Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2023Article
- A modified pixel value ratio based on contralateral normal bone: a novel reliable indicator for distraction osteogenesis.American journal of translational research · 2023Article
- Body composition and osteoporotic fracture using anthropometric prediction equations to assess muscle and fat masses.Journal of cachexia, sarcopenia and muscle · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe association between hemoglobin (Hb) level including anemia and fracture has not been studied thoroughly. MATERIALS AND
methods197, 187 adults ≥ 50 years from the National Health Insurance Service of Korea were studied. Hb was determined during health screening examinations in 2004 or 2005. From 1 January 2006, participants were followed up for fracture until 31 December 2013. Hb levels (g/dL) were categorized into five groups, with normal hemoglobin levels subdivided into three groups (low normal, normal, and high normal Hb): < 13, ≥ 13 to < 14, ≥ 14 to < 16, ≥ 16 to < 17, 17 for men and < 12, ≥ 12 to < 13, ≥ 13 to < 14, ≥ 14 to < 16, ≥ 16 for women. Anemia was defined as Hb < 13 g/dL and < 12 g/dL for men and women, respectively. Cox proportional hazards regression was used to determine the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for fracture according to Hb.
resultsCompared to individuals with normal Hb, those with anemia and low normal Hb were associated with significantly increased risk of fracture. In women, those with anemia had a higher risk for any (aHR 1.11, 95% CI 1.05-1.17), hip (aHR 1.27, 95% CI 1.01-1.59), and radius fracture (aHR 1.15, 95% CI 1.05-1.25). In men, those with anemia had a higher risk for any (aHR 1.37, 95% CI 1.23-1.51), vertebral (aHR 1.33, 95% CI 1.15-1.53), and hip fracture (aHR 1.64, 95% CI 1.30-2.08). This risk-enhancing association was preserved among various subgroups.
conclusionAmong adults ≥ 50 years, anemia and low normal Hb are risk factors for fracture.
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