ArticleNeuroradiology2021
Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.
Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03345069 (Early Prediction of Cognitive and Motor Deficits Using Advanced MRI in Very Preterm Infants), which is not on this map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Prediction of Cognitive and Motor Deficits Using Advanced MRI in Very Preterm Infants
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Long Term Developmental Consequences of Short Apneas and Periodic Breathing in Preterm Infants.Pediatric pulmonology · 2025Article
- Early life brain network connectivity antecedents of executive function in children born preterm.Communications biology · 2025Article
- Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage.Scientific reports · 2024Article
- Developmental consequences of short apneas and periodic breathing in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Neuroimaging of structural and functional connectivity in preterm infants with intraventricular hemorrhage.Seminars in perinatology · 2022Review
- Clinical application of cervical shear wave elastography in predicting the risk of preterm delivery in DCDA twin pregnancy.BMC pregnancy and childbirth · 2022Article
- The Impact of Different Degrees of Intraventricular Hemorrhage on Mortality and Neurological Outcomes in Very Preterm Infants: A Prospective Cohort Study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
purposeVery preterm (VPT) infants are at high risk for motor and behavioral deficits. We investigated microstructural differences using diffusion tensor imaging (DTI) among VPT infants with different grades of intraventricular hemorrhage (IVH), their association with early motor function and temperament ratings, and the potential moderating effect of IVH severity on the above structure-function relations.
methodsFifty-seven VPT (≤32 weeks gestational age) infants with IVH (Low Grade (Papile grading I/II): 42; High Grade (III/IV): 15) were studied. DTI was acquired between 39 and 44 weeks postmenstrual age and was analyzed using the tract-based spatial statistics approach. Early motor function and temperament were assessed at 3-month corrected age based on the Hammersmith Infant Neurological Examination (HINE) and Infant Behavioral Questionnaire - Revised, Short Version (IBQ-R-S), respectively.
resultsSignificantly lower fractional anisotropy and higher mean, axial, and/or radial diffusivity were found in VPT infants with High Grade IVH compared to Low Grade IVH (p < 0.05). Significant associations were found between DTI metrics and motor function in both IVH groups and between DTI and Fear temperament ratings in the High Grade IVH Group (all p < 0.05). IVH severity had a significant moderating effect on the relation between DTI and motor and Fear ratings (p < 0.05).
conclusionDTI is a sensitive neuroimaging biomarker providing a refined understanding of the impact and location of differing severities of IVH on the developing white matter of VPT infants. Early motor and behavioral outcomes are associated with microstructural changes that are influenced by severity of IVH.
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