ArticleArchives of toxicology2021
Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment.
Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence.Current research in toxicology · 2026Article
- Systematic evaluation of the evidence base on ethylCurrent research in toxicology · 2026Review
- Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data.Current research in toxicology · 2026Article
- Corrosion inhibition andRSC advances · 2025Article
- Systematic evaluation of the evidence base on methylCurrent research in toxicology · 2025Review
- Molecular response ofCurrent research in toxicology · 2025Article
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells.Toxicology letters · 2024Article
- Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay.Frontiers in toxicology · 2024Article
- Towards a future regulatory framework for chemicals in the European Union - Chemicals 2.0.Regulatory toxicology and pharmacology : RTP · 2023Article
- Digital Transformation in Toxicology: Improving Communication and Efficiency in Risk Assessment.ACS omega · 2023Review
- A New Interpretation of Relative Importance on an Analysis of Per and Polyfluorinated Alkyl Substances (PFAS) Exposures on Bone Mineral Density.International journal of environmental research and public health · 2023Article
- New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project.Frontiers in toxicology · 2023Review
- A framework for establishing scientific confidence in new approach methodologies.Archives of toxicology · 2022Review
- A new approach to the classification of carcinogenicity.Archives of toxicology · 2022Article
- Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation.International journal of molecular sciences · 2022Article
- Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi.Archives of toxicology · 2022Review
- Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics.Open biology · 2022Review
- Article
- Invited Perspective: Prioritizing Chemical Testing and Evaluation Using ValidatedEnvironmental health perspectives · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In view of the need to enhance the assessment of consumer products called for in the EU Chemicals Strategy for Sustainability, we developed a methodology for evaluating hazard by combining information across different systemic toxicity endpoints and integrating the information with new approach methodologies. This integrates mechanistic information with a view to avoiding redundant in vivo studies, minimising reliance on apical endpoint tests and ultimately devising efficient testing strategies. Here, we present the application of our methodology to carcinogenicity assessment, mapping the available information from toxicity test methods across endpoints to the key characteristics of carcinogens. Test methods are deconstructed to allow the information they provide to be organised in a systematic way, enabling the description of the toxicity mechanisms leading to the adverse outcome. This integrated approach provides a flexible and resource-efficient means of fully exploiting test methods for which test guidelines are available to fulfil regulatory requirements for systemic toxicity assessment as well as identifying where new methods can be integrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.