ArticleSocial cognitive and affective neuroscience2023
The orbitofrontal cortex, food reward, body weight and obesity.
Article in Social cognitive and affective neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Longitudinal PET/CT-Derived Body Composition Changes During Systemic Therapy in Patients with Lung Cancer.Diagnostics (Basel, Switzerland) · 2026Article
- Large-scale brain network interactions differentiate sweet, sour, and salty food cues during visual processing.Scientific reports · 2026Article
- Joint effect of uncertainty-of-outcome and calorie content on food preference.Scientific reports · 2026Article
- Acute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence: the mediating role of prefrontal cortical activity.Frontiers in nutrition · 2026Article
- Chocolate odor enhances resistance exercise performance through appetite suppression in the fasted state: an exploratory study.Frontiers in physiology · 2026Article
- Altered eating experience during GLP-1 receptor agonist therapy: a sensory-liking-wanting framework for food preference and nutritional behaviour.Frontiers in nutrition · 2026Review
- The plasticity of olfactory learning in culinary students and matched controls.Brain imaging and behavior · 2025Article
- Savoring Satiety: An Exploratory Analysis of the Neural Correlates of Sensory-Specific Satiety.Nutrients · 2025Article
- Emotion, Motivation, Reasoning, and How Their Brain Systems Are Related.Brain sciences · 2025Review
- Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety.Science (New York, N.Y.) · 2025Article
- Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Neural Basis of Salt Perception: A Focus on Potassium Chloride as a Sodium Alternative.Life (Basel, Switzerland) · 2025Article
- Beauty in the shadow of neurodegenerative disease: a narrative review on aesthetic experience, neural mechanisms, and therapeutic frontiers.Frontiers in human neuroscience · 2025Review
- Neuronal Sequences and dynamic coding of water-sucrose categorization in rat gustatory cortices.iScience · 2024Article
- Distributed representations of behaviour-derived object dimensions in the human visual system.Nature human behaviour · 2024Article
- Diet quality during pregnancy, adolescent brain morphology, and cognitive performance in a population-based cohort.The American journal of clinical nutrition · 2024Article
- Distributed representations of behavior-derived object dimensions in the human visual system.bioRxiv : the preprint server for biology · 2024Article
- Does 'portion size' matter? Brain responses to food and non-food cues presented in varying amounts.Appetite · 2024Article
- A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition.eLife · 2024Article
- Expression of guanylate cyclase C in human prefrontal cortex depends on sex and feeding status.Frontiers in molecular neuroscience · 2024Article
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Abstract
In primates including humans, the orbitofrontal cortex is the key brain region representing the reward value and subjective pleasantness of the sight, smell, taste and texture of food. At stages of processing before this, in the insular taste cortex and inferior temporal visual cortex, the identity of the food is represented, but not its affective value. In rodents, the whole organisation of reward systems appears to be different, with reward value reflected earlier in processing systems. In primates and humans, the amygdala is overshadowed by the great development of the orbitofrontal cortex. Social and cognitive factors exert a top-down influence on the orbitofrontal cortex, to modulate the reward value of food that is represented in the orbitofrontal cortex. Recent evidence shows that even in the resting state, with no food present as a stimulus, the liking for food, and probably as a consequence of that body mass index, is correlated with the functional connectivity of the orbitofrontal cortex and ventromedial prefrontal cortex. This suggests that individual differences in these orbitofrontal cortex reward systems contribute to individual differences in food pleasantness and obesity. Implications of how these reward systems in the brain operate for understanding, preventing and treating obesity are described.
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