Evidence map›Paper›PMID 33830247›Full record

ArticleThe Journal of nutrition2021

Wasting and Stunting in Infants and Young Children as Risk Factors for Subsequent Stunting or Mortality: Longitudinal Analysis of Data from Malawi, South Africa, and Pakistan.

Charlotte M Wright, John Macpherson, Ruth Bland, Per Ashorn, Shakila Zaman, Frederick K Ho

Open access · hybridAbstract read
In one paragraph

Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Malaria Incidence, Growth, and their Relationship among a Cohort of Malawian Children.The American journal of tropical medicine and hygiene · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Charlotte M WrightDepartment of Child Health, School of Medicine, Nursing and Dentistry, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-6256-6315
John MacphersonInstitute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Ruth BlandInstitute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-1675-9268
Per AshornCenter for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland.ORCID 0000-0003-2311-2593
Shakila ZamanDepartment of Public Health, University of Health Sciences, Lahore, Pakistan.
Frederick K HoInstitute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-7190-9025
University of Glasgow · GBTampere University Hospital · FIUniversity of Health Sciences Lahore · PKUniversity of the Witwatersrand · ZA

Funding

Chief Scientist Office CZH/4/676Medical Research Council MR/K500847/1Wellcome TrustWellcome Trust 063009/Z/00/2
6 · The paper itself

Abstract

backgroundFew studies have had sufficient longitudinal data to track how different malnourished states relate to mortality at different ages and interrelate over time.

objectivesThis study aims to describe the RRs and proportions of mortality associated with wasting and stunting and the pathways into and out of these nutritional states.

methodsLongitudinal growth data sets collected for children ages 0-24 months from Malawi, South Africa, and Pakistan were combined (n = 5088). Children were classified as deceased, wasted (weight for height < -2 SD; 1-4%), stunted (length < -2SD; 20-47%), or wasted and stunted (WaSt; 2-5%) at ages 3, 6, 9, 12, 18, and 24 months. Mixed-effects Cox models were used to study the association between nutritional status and mortality.

resultsBy age 3 months, 20% of children were already stunted, rising to 49% by 24 months, while wasting (4.2% and 2.2% at 3 months, respectively) and WaSt (0.9% and 3.7% at 24 months, respectively) were less common. The HR for mortality in WaSt was 9.5 (95% CI, 5.9-15), but 60% of WaSt-associated mortality occurred at 3-6 months. Wasting or WaSt was associated with 10-23% of deaths beyond 6 months, but in the second year over half of deaths occurred in stunted, nonwasted children. Stunting persisted in 82% of children and wasting persisted in 44%. Wasted children were more likely than nonwasted, nonstunted children to become stunted (RR, 1.93; 95% CI, 1.7-2.2), but 94% of children who progressed to stunting had not been wasted in the prior period.

conclusionsWaSt greatly increased the risk of death, particularly in very young infants, but more deaths overall were associated with stunting. Most stunting appeared to be either intrauterine in origin or arose in children without prior wasting. Either stunting and wasting represent alternative responses to restricted nutrition, or stunting also has other, nonnutritional causes.

Indexed as

Wasting SyndromeChildChild, PreschoolGrowth DisordersHumansInfantInfant, NewbornMalawiPakistanRisk FactorsSouth Africacohort studygrowthinfantlower- and middle-income countriesmalnutritionmortalityoutcomesstuntingwastingyoung child

Identifiers

PMID33830247
PMCPMC8245889
OpenAlexW3132525984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.