ArticleJAMA network open2021
Long-term Risk of Hypertension After Surgical Repair of Congenital Heart Disease in Children.
Article in JAMA network open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Captopril to Lisinopril Conversion in Pediatric Cardiothoracic Surgery Patients Less Than 7 Years of Age (RISE-7).Pediatric cardiology · 2024Article
- Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study.Pediatric nephrology (Berlin, Germany) · 2023Article
- New Hypertension After Pregnancy in Patients With Heart Disease.Journal of the American Heart Association · 2023Article
- Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children.Journal of the American Heart Association · 2023Article
- Global, regional, and national time trends in mortality for congenital heart disease, 1990-2019: An age-period-cohort analysis for the Global Burden of Disease 2019 study.EClinicalMedicine · 2022Article
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
Importance: The long-term risk of hypertension in children after surgery for congenital heart disease (CHD) is unclear. Objective: To assess the incidence of hypertension after cardiac surgery in children with CHD. Design, Setting, and Participants: A multicenter retrospective matched cohort study was conducted in Ontario, Canada, using administrative databases. A total of 3600 children with surgical repair of CHD were matched to 10 children (n = 36 000) from the general population without CHD on age, sex, index date, rurality, and neighborhood income. Main Outcomes and Measures: Diagnosis of hypertension over a median follow-up time of 9.8 years (interquartile range, 6.8-12.9 years) after surgery. The last follow-up was March 31, 2019. Results: Overall, in 3600 children with surgical repair of CHD, the median age at first surgery was 150 days (interquartile range, 40-252 days) and 2005 (55.7%) were boys. During follow-up, 445 (12.4%) children with surgical repair of CHD developed hypertension compared with 398 (1.1%) in the matched control group. The incidence rate of hypertension in children who received surgery for CHD was 141.3 (95% CI, 128.8-155.1) per 10 000 person-years compared with children in the matched control group, who had a rate of 11.1 (95% CI, 10.1-12.3) per 10 000 person-years. The risk of hypertension was higher in children with index surgical dates at an age of less 150 days compared with those who had surgical dates at an age of 150 days or older (P = .006 for interaction). The risk of hypertension was increased in children with more complex surgery, particularly children with hypoplastic left heart syndrome (49 of 140 [35.0%]), and in children who received dialysis (22 of 126 [17.5%]; hazard ratio, 1.67; 95% CI, 1.09-2.56) during the index cardiac surgery hospitalization. Conclusions and Relevance: The incidence of long-term hypertension in this study was 12 times higher in children with surgical repair of CHD compared with children in the matched control group. The findings suggest that interventions aimed at reducing the long-term risk of hypertension after cardiac surgery in this population are needed.
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