ArticleThe international journal of neuropsychopharmacology2021
Sex Differences in the Association of Cigarette Craving With Insula Structure.
Article in The international journal of neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Comparing neuromodulation targets to reduce cigarette craving and withdrawal: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Effect of glucagon-like peptide-1 receptor agonists on cigarette smoking consumption in type 2 diabetes patients: study protocol of a randomized, parallel -controlled clinical trial.Frontiers in clinical diabetes and healthcare · 2026Article
- rTMS for Co-occurring Psychiatric and Substance Use Disorders: Narrative Review and Future Directions.Current addiction reports · 2024Article
- Unraveling neural complexity: Exploring brain entropy to yield mechanistic insight in neuromodulation therapies for tobacco use disorder.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex.Molecular psychiatry · 2023Article
- Negative affect and craving during abstinence from smoking are both linked to default mode network connectivity.Drug and alcohol dependence · 2023Article
- Nicotine dependence and insula subregions: functional connectivity and cue-induced activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Functional connectivity gradients of the insula to different cerebral systems.Human brain mapping · 2023Article
- Neural-hematopoietic-inflammatory axis in nonsmokers, electronic cigarette users, and tobacco smokers.Physiological reports · 2022Article
- Cortical thickness and related depressive symptoms in early abstinence from chronic methamphetamine use.Addiction biology · 2022Article
- The relationship between craving and insular morphometry in regular cocaine users: Does sex matter?Addiction biology · 2022Article
- Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex: A comparison between early-onset smokers and late-onset smokers.Frontiers in psychiatry · 2022Article
- Brain Magnetic Resonance Imaging Features of Nicotine-Dependent Individuals and Its Correlation with Polymorphisms of Dopamine D Receptor Gene.Contrast media & molecular imaging · 2022Article
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundCigarette craving, which can negatively impact smoking cessation, is reportedly stronger in women than in men when they initiate abstinence from smoking. Identifying approaches to counteract craving in people of different sexes may facilitate the development of personalized treatments for Tobacco Use Disorder, which disproportionately affects women. Because cigarette craving is associated with nicotine dependence and structure of the insula, this study addressed whether a person's sex influences these associations.
methodsThe research participants (n = 99, 48 women) reported daily cigarette smoking and provided self-reports of nicotine dependence. After overnight abstinence from smoking, they underwent structural magnetic resonance imaging scanning to determine cortical thickness of the left and right anterior circular insular sulcus, and self-rated their cigarette craving before and after their first cigarette of the day.
resultsWomen reported stronger craving than men irrespective of smoking condition (i.e., pre- and post-smoking) (P = .048), and smoking reduced craving irrespective of sex (P < .001). A 3-way interaction of sex, smoking condition, and right anterior circular insular sulcus thickness on craving (P = .033) reflected a negative association of cortical thickness with pre-smoking craving in women only (P = .012). No effects of cortical thickness in the left anterior circular insular sulcus were detected. Nicotine dependence was positively associated with craving (P < .001) across groups and sessions, with no sex differences in this association.
conclusionsA negative association of right anterior insula thickness with craving in women only suggests that this region may be a relevant therapeutic target for brain-based smoking cessation interventions in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.