Evidence map›Paper›PMID 33829714›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2021

Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.

Robert M Burkes, David J Couper, Igor Z Barjaktarevic, Christopher B Cooper, Wassim W Labaki, Meilan K Han, Prescott G Woodruff, Stephen C Lazarus, Trisha M Parekh, Robert Paine and 7 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Robert M BurkesDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States.
David J CouperGillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States.
Igor Z BarjaktarevicDivision of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States.
Christopher B CooperDepartments of Medicine and Physiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Meilan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California-San Francisco, San Francisco, California, United States.
Stephen C LazarusDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California-San Francisco, San Francisco, California, United States.
Trisha M ParekhDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of Alabama-Birmingham, Birmingham, Alabama, United States.
Robert PaineDivision of Pulmonary Medicine, University of Utah, Salt Lake City, Utah, United States.
Alejandro P ComellasDivision of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, Iowa City, Iowa, United States.
Russell P BowlerDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Hospital, Denver, Colorado, United States.
Laura R LoehrDivision of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States.
Nirupama PutchaDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Robert A WiseDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Todd T BrownDivision of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, United States.
M Bradley DrummondDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States.
University of North Carolina at Chapel Hill · USJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Michigan–Ann Arbor · USJewish Hospital · USUniversity of Alabama at Birmingham · USUniversity of Iowa · USUniversity of Utah · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
Cathelicidin and Vitamin D: Impact on Populations At-Risk and with COPDR01HL125432 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DRUMMOND, MICHAEL BRADLEY · 2015 to 2019
$3.1M
Clinical Significance of the Antimicrobial Peptide Cathelicidin in Acute Exacerbations of COPDF32HL143867 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURKES, ROBERT M · 2018 to 2019
$142k
NHLBI NIH HHS F32 HL143867NHLBI NIH HHS F32HL143867NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900013C/NHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS R01 HL125432NHLBI NIH HHS R01HL125432NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

introductionAge and vitamin D levels may affect symptom burden in chronic obstructive pulmonary disease (COPD). We used the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) to determine independent associations between vitamin D levels and COPD symptoms in different age strata.

methodsSerum 25-hydroxy (OH)-vitamin D levels were modeled continuously and categorically (<20 ng/ml versus ≥20 ng/ml). Stratifying by age group (middle-age: 40-64 years old and older: >65 years old), multivariable modeling was performed to identify relationships between 25-OH-vitamin D levels and the COPD Assessment Test (CAT), the modified Medical Research Council score (mMRC), the St George's Respiratory Questionnaire (SGRQ) total and subdomain scores, the Veterans' Specific Activity Questionnaire, and the 6-minute walk test distance.

resultsInIn the middle-aged group, each 5 ng/ml higher 25-OH-vitamin D level was independently associated with more favorable CAT score (-0.35 [-0.67 to -0.03], DISCUSSION: When controlled for clinically relevant covariates, higher 25-OH-vitamin D levels are associated with more favorable respiratory-specific symptoms and quality-of-life assessments in middle-age but not older COPD individuals. Study of the role of vitamin D supplementation in the symptom burden of younger COPD patients is needed.

Indexed as

COPDCOPD epidemiologyCOPD outcomesCOPD symptomsvitamin D

Identifiers

PMID33829714
PMCPMC8237982
OpenAlexW3151685716

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.