Evidence map›Paper›PMID 33829696›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2021

[Morin Improves Experimental Autoimmune Thyroiditis in Rats via NLRP3/Caspase-1 Pathway].

Ya-Jun Sun, Yan-Fang Zhang, Hui-Min Xu, Yong-Tao Ma, Chun Li, Chun-Hong Nie, Min Zhao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ya-Jun SunDepartment of Endocrinology, Kaifeng Children's Hospital, Kaifeng 475000, China.
Yan-Fang ZhangDepartment of Endocrinology, Kaifeng Children's Hospital, Kaifeng 475000, China.
Hui-Min XuPICU, Kaifeng Children's Hospital, Kaifeng 475000, China.
Yong-Tao MaDepartment of Emergency, Kaifeng Children's Hospital, Kaifeng 475000, China.
Chun LiDepartment of Endocrinology, Kaifeng Children's Hospital, Kaifeng 475000, China.
Chun-Hong NieLaboratory of Kaifeng Children's Hospital, Kaifeng 475000, China.
Min ZhaoDepartment of Respiratory and Critical Care Medicine, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, China.
Kaifeng City Children's Hospital · CNHenan University Huaihe Hospital and Huaihe Clinical Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of morin-regulated NLRP3/Caspase-1 pathway on experimental autoimmune thyroiditis in rats.

methodsThe rats were randomly assigned to 6 groups: control group, experimental autoimmune thyroiditis group (EAT), low-, medium- and high-dose morin groups (post-modeling gavage of 50, 100 and 200 mg/kg morin hydrate per day for 6 weeks) and tripterygium wilfordii polyglycosides group (LGT group, post-modeling gavage of 6.25 mg/kg tripterygium wilfordii polyglycosidesper day for 6 weeks). Except for the control group, the rat model of experimental autoimmune thyroiditis was established by subcutaneous injection of 0.1 mL incomplete Freund's adjuvant containing porcine thyroglobulin. The levels of serum thyroglobulin (TgAb), thyroid peroxidase antibody (TPOAb), triiodothyronine (T3) and tetraiodothyronine (T4) in serum were detected by radioimmunoassay. The mRNA levels of interleukin-17 (

resultsCompared with the EAT group, serum levels of TPOAb, TgAb, T3, and T4 in low-, medium- and high-dose Morin groups and LGT group were reduced (

conclusionThe findings suggest that Morin improved experimental autoimmune thyroiditis in rats through regulating NLRP3/Caspase-1 pathway.

Indexed as

Thyroiditis, AutoimmuneAnimalsCaspase 1FlavonesFlavonoidsInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinProtein CarbonylationRatsSwineCaspase 1FlavonesFlavonoidsInterleukin-1betamorinNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratExperimental autoimmune thyroiditisInflammationMorin hydrateNLRP3/Caspase-1

Identifiers

PMID33829696
PMCPMC10408906
OpenAlexW3146495974

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.