ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Functional decline in the aphasic variant of Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Behavioral Treatment for Speech and Language in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech: A Systematic Review.Neuropsychology review · 2024Pooled it
- Efficacy of Communication Bridge-2 for primary progressive aphasia: A randomized controlled trial of communication intervention.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Communication Bridge-2 randomized controlled trial: Recruitment and baseline features.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Lessons From the Communication Bridge Trials: Advancing Meaningful Dyadic Interventions Toward Implementation.Journal of speech, language, and hearing research : JSLHR · 2026Review
- Care Partner Perceptions of Conversation Difficulties, Strategy Use, and Psychosocial Impacts in Primary Progressive Aphasia: A Descriptive Study Using the PCI-DAT.Brain sciences · 2026Article
- Face and Content Validation of the 10-Item Communicative Participation Item Bank General Short Form for Primary Progressive Aphasia: A Cognitive Interviewing Study.American journal of speech-language pathology · 2025Article
- Safety and Efficacy of Different Therapeutic Interventions for Primary Progressive Aphasia: A Systematic Review.Journal of clinical medicine · 2025Review
- Decline in activities of daily living in the rarer dementias.General psychiatry · 2025Review
- Atypical Presentations of Alzheimer Disease.Continuum (Minneapolis, Minn.) · 2024Review
- Use and Perceived Effectiveness of Communication Modes Reported by Persons With Primary Progressive Aphasia.American journal of speech-language pathology · 2023Article
- Identifying care problem clusters and core care problems of older adults with dementia for caregivers: a network analysis.Frontiers in public health · 2023Article
- Person-centered intervention response in primary progressive aphasia: A secondary analysis of the Communication Bridge-2 randomized clinical trial.Alzheimer's & dementia (New York, N. Y.)Article
- Assessment of disease impact through health-related quality of life measurement in primary progressive aphasia.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
introductionPrimary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD). Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time.
methodsActivities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPA
resultsGroups did not differ in demographics or aphasia severity at baseline, yet overall and subdomain scores of the ADLQ were significantly worse for PPA DISCUSSION: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.