ArticleCardiovascular engineering and technology2021
Analysis of Turbulence Effects in a Patient-Specific Aorta with Aortic Valve Stenosis.
Article in Cardiovascular engineering and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Patient-specific hemodynamic assessment using experimental and computational approaches in anomalous aortic origin of the coronary artery: Case study.JTCVS techniques · 2026Article
- Hemodynamic Metrics and Arterial Dysfunction: Insights From a Novel Microfluidic Device.International journal for numerical methods in biomedical engineering · 2026Article
- Utility of Computational Modeling in Reassessing the Threshold for Intervention and Progression into Type A Aortic Dissection.Biomedicines · 2026Article
- Transient numerical simulation of hemodynamics in bioprosthetic heart valves: insights into valve sizing and thrombosis risk.International journal of computer assisted radiology and surgery · 2026Article
- Hemodynamic Alteration in Aortic Valve Stenosis: CFD Insights from Leaflet-Resolved Models.Bioengineering (Basel, Switzerland) · 2025Article
- A combined 4D flow MR imaging and fluid-structure interaction analysis of ascending thoracic aortic aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- Investigation of hemodynamic bulk flow patterns caused by aortic stenosis using a combined 4D Flow MRI-CFD framework.PLoS computational biology · 2025Article
- Characteristics of transition to turbulence in a healthy thoracic aorta using large eddy simulation.Scientific reports · 2025Article
- An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation.Scientific reports · 2025Article
- Mechano-electrical-fluid interaction left-ventricle model for numerical evaluation of aortic valve hemodynamics.Frontiers in bioengineering and biotechnology · 2025Article
- A Synergistic Overview between Microfluidics and Numerical Research for Vascular Flow and Pathological Investigations.Sensors (Basel, Switzerland) · 2024Review
- A comprehensive MRI-based computational model of blood flow in compliant aorta using radial basis function interpolation.Biomedical engineering online · 2024Article
- Accelerated simulation methodologies for computational vascular flow modelling.Journal of the Royal Society, Interface · 2024Review
- Differences in blood flow dynamics between balloon- and self-expandable valves in patients with aortic stenosis undergoing transcatheter aortic valve replacement.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Wall shear stress and pressure patterns in aortic stenosis patients with and without aortic dilation captured by high-performance image-based computational fluid dynamics.PLoS computational biology · 2023Article
- Assessing the impact of turbulent kinetic energy boundary conditions on turbulent flow simulations using computational fluid dynamics.Scientific reports · 2023Article
- Impact of dobutamine stress on diastolic energetic efficiency of healthy left ventricle: anFrontiers in cardiovascular medicine · 2023Article
- Existing and Emerging Approaches to Risk Assessment in Patients with Ascending Thoracic Aortic Dilatation.Journal of imaging · 2022Review
- The Impact of a New Arterial Intravascular Pump on Aorta Hemodynamic Surrounding: A Numerical Study.Bioengineering (Basel, Switzerland) · 2022Article
- Quantitative evaluation of aortic valve regurgitation in 4D flow cardiac magnetic resonance: at which level should we measure?BMC medical imaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Blood flow in the aorta is often assumed laminar, however aortic valve pathologies may induce transition to turbulence and our understanding of turbulence effects is incomplete. The aim of the study was to provide a detailed analysis of turbulence effects in aortic valve stenosis (AVS).
methodsLarge-eddy simulation (LES) of flow through a patient-specific aorta with AVS was conducted. Magnetic resonance imaging (MRI) was performed and used for geometric reconstruction and patient-specific boundary conditions. Computed velocity field was compared with 4D flow MRI to check qualitative and quantitative consistency. The effect of turbulence was evaluated in terms of fluctuating kinetic energy, turbulence-related wall shear stress (WSS) and energy loss.
resultsOur analysis suggested that turbulence was induced by a combination of a high velocity jet impinging on the arterial wall and a dilated ascending aorta which provided sufficient space for turbulence to develop. Turbulent WSS contributed to 40% of the total WSS in the ascending aorta and 38% in the entire aorta. Viscous and turbulent irreversible energy losses accounted for 3.9 and 2.7% of the total stroke work, respectively.
conclusionsThis study demonstrates the importance of turbulence in assessing aortic haemodynamics in a patient with AVS. Neglecting the turbulent contribution to WSS could potentially result in a significant underestimation of the total WSS. Further work is warranted to extend the analysis to more AVS cases and patients with other aortic valve diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.