Evidence map›Paper›PMID 33829378›Full record

ArticleNeurocritical care2021

Association Between Ionized Calcium Level and Neurological Outcome in Endovascularly Treated Patients with Spontaneous Subarachnoid Hemorrhage: A Retrospective Cohort Study.

Danny Epstein, Yaacov Freund, Erez Marcusohn, Tarek Diab, Erez Klein, Aeyal Raz, Ami Neuberger, Asaf Miller

Registry-linked trialAbstract read
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In one paragraph

Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06235749 (Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06235749 narecruitingnot on this mapstarted 2023, after this paper: background citation

Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery

TypeinterventionalSponsorRambam Health Care CampusRan2023 to 2028Enrolled1,180ConditionsElective Cesarean DeliveryArmsCalcium Gluconate 10%, sodium chloride 0.9%
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Hydroelectrolytic syndromes in neuroanesthesia and neurocritical care.World journal of critical care medicine · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Danny Epstein *Critical Care Division, Rambam Health Care Campus, Haifa, Israel.
Yaacov Freund *Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Efron St 1, Haifa, 35254, Israel. yaacov.fr@gmail.com.ORCID 0000-0001-8636-3539
Erez MarcusohnDepartment of Cardiology, Rambam Health Care Campus, Haifa, Israel.
Tarek DiabCritical Care Division, Rambam Health Care Campus, Haifa, Israel.
Erez KleinDepartment of Diagnostic Imaging, Rambam Health Care Campus, Haifa, Israel.
Aeyal RazRuth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Efron St 1, Haifa, 35254, Israel.
Ami NeubergerRuth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Efron St 1, Haifa, 35254, Israel.
Asaf MillerMedical Intensive Care Unit, Rambam Health Care Campus, Haifa, Israel.
Rambam Health Care Campus · ILTechnion – Israel Institute of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpontaneous subarachnoid hemorrhage (SSAH) is associated with significant morbidity and mortality. Pathophysiological processes following initial bleeding are complex and not fully understood. In this study, we aimed to determine whether a low level of ionized calcium (Ca

methodsThis was a retrospective single-center cohort study of all patients admitted for SSAH between January 1, 2009, and April 31, 2020. The primary outcome was an unfavorable neurological status at discharge, defined as a modified Rankin Scale score greater than or equal to 3. Secondary outcomes were the development of early hydrocephalus and symptomatic vasospasm. Multivariable logistic regression was performed to determine whether Ca

resultsA total of 255 patients were included in the final analysis. Hypocalcemia, older age, admission Glasgow Coma Scale (GCS) score, and admission Hunt-Hess classification scale (H&H) grades IV and V were independently associated with unfavorable neurological outcome, with adjusted odds ratios (ORs) of 1.93 (95% confidence interval [CI] 1.1-3.4; p = 0.02) for each 0.1 mmol L

conclusionsOur study shows that hypocalcemia is associated with worse neurological outcome at discharge and development of early hydrocephalus in endovascularly treated patients with SSAH. Potential mechanisms include calcium-induced coagulopathy and higher blood pressure. Trials are needed to assess whether correction of hypocalcemia will lead to improved outcomes.

Indexed as

CalciumSubarachnoid HemorrhageCohort StudiesGlasgow Coma ScaleHumansRetrospective StudiesTreatment OutcomeCalciumCoagulation abnormalitiesHypocalcemiaIonized calciumSpontaneous subarachnoid hemorrhage

Identifiers

PMID33829378
OpenAlexW3149075906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.