Evidence map›Paper›PMID 33829353›Full record

ReviewStem cell reviews and reports2021

Regenerative Potential of DPSCs and Revascularization: Direct, Paracrine or Autocrine Effect?

Vincenzo Mattei, Stefano Martellucci, Fanny Pulcini, Francesca Santilli, Maurizio Sorice, Simona Delle Monache

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reviews and reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  18. DMP1-mediated transformation of DPSCs to CD31Frontiers in cell and developmental biology · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Vincenzo MatteiBiomedicine and Advanced Technologies Rieti Center, Sabina Universitas, 02100, Rieti, Italy.
Stefano MartellucciBiomedicine and Advanced Technologies Rieti Center, Sabina Universitas, 02100, Rieti, Italy.
Fanny PulciniDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100, L'Aquila, Italy.
Francesca SantilliBiomedicine and Advanced Technologies Rieti Center, Sabina Universitas, 02100, Rieti, Italy.
Maurizio SoriceDepartment of Experimental Medicine, "Sapienza" University, 00161, Rome, Italy.
Simona Delle MonacheDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100, L'Aquila, Italy. simona.dellemonache@univaq.it.ORCID 0000-0002-8153-915X
Sapienza University of Rome · ITUniversity of L'Aquila · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new source of mesenchymal stem cells has recently been discovered, the so-called dental pulp derived stem cells (DPSCs) which therefore could represent potentially tools for regenerative medicine. DPSC originate from the neural crest and are physiologically involved in dentin homeostasis; moreover, they contribute to bone remodeling and differentiation into several tissues including cartilage, bone, adipose and nervous tissues. DPSCs have also been shown to influence the angiogenesis process, for example through the release of secretory factors or by differentiating into vascular and/or perivascular cells. Angiogenesis, that has a pivotal role in tissue regeneration and repair, is defined as the formation of new vessels from preexisting vessels and is mediated by mutual and reciprocal interactions between endothelial cells and perivascular cells. It is also known that co-cultures of perivascular and endothelial cells (ECs) can form a vascular network in vitro and also in vivo. Since DPSCs seem to have characteristics similar to pericytes, understanding the possible mechanism of interaction between DPSCs and ECs during neo-angiogenesis is dramatically important for the development of advanced clinical application in the field of regeneration.

Indexed as

Dental PulpMesenchymal Stem CellsCell DifferentiationEndothelial CellsPericytesStem CellsAngiogenesisDental pulp stem cellsRegenerative potentialRevascularizationStem cells differentiation

Identifiers

PMID33829353
PMCPMC8553678
OpenAlexW3151159720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.