Evidence map›Paper›PMID 33829308›Full record

Trial reportPsychopharmacology2021

Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity.

Haruka Ochiai, Tetsuya Shiga, Hiroshi Hoshino, Sho Horikoshi, Kazuko Kanno, Tomohiro Wada, Yusuke Osakabe, Itaru Miura, Hirooki Yabe

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Haruka OchiaiDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan. haruka-o@fmu.ac.jp.ORCID http://orcid.org/0000-0002-6768-2961
Tetsuya ShigaDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Hiroshi HoshinoDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Sho HorikoshiDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Kazuko KannoDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Tomohiro WadaDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Yusuke OsakabeDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Itaru MiuraDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Hirooki YabeDepartment of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Fukushima Medical University · JP

Funding

Japan Society for the Promotion of Science JP16K19777
6 · The paper itself

Abstract

rationaleAs a treatment for cognitive dysfunction in schizophrenia, oxytocin nasal sprays potentially improve social cognition, facial expression recognition, and sense of smell. Mismatch negativity (MMN) is an event-related potential (ERP) reflecting auditory discrimination while MMN deficits reflect cognitive function decline in schizophrenia.

objectivesTo determine whether oxytocin nasal spray affects auditory MMN

methodsWe measured ERPs in healthy subjects during an auditory oddball task, both before and after oxytocin nasal spray administration. Forty healthy subjects were randomly assigned to either the oxytocin or placebo group. ERPs were recorded during the oddball task for all subjects before and after a 24 international unit (IU) intranasal administration, and MMN was compared between the two groups.

resultsParticipants who received oxytocin had significantly shorter MMN latencies than those who received a placebo. Oxytocin had no significant effect on the Change in MMN amplitude.

conclusionsThe shortened MMN latencies that were observed after oxytocin nasal spray administration suggest that oxytocin may promote the comparison-decision stage.

Indexed as

Nasal SpraysAcoustic StimulationAdultAuditory PerceptionDiscrimination, PsychologicalDouble-Blind MethodElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleOxytocinSchizophreniaYoung AdultNasal SpraysOxytocinAuditoryCognitive functionEvent-related potentialMismatch negativityOxytocin

Identifiers

PMID33829308
OpenAlexW3142968425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.