Evidence map›Paper›PMID 33829277›Full record

ArticleAnalytical and bioanalytical chemistry2021

Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization mass spectrometry imaging.

Amanda Vaughn, Rachel J DeHoog, Livia S Eberlin, Dean R Appling

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. [Performance Comparison of Two Cryosection Embedding Agents Used for Desorption Electrospray Ionization Mass Spectrometry Imaging].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amanda Vaughn *Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA.
Rachel J DeHoog *Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Livia S EberlinDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Dean R ApplingDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA. dappling@austin.utexas.edu.ORCID http://orcid.org/0000-0002-5309-3015
The University of Texas at Austin · US

Funding

NIH HHS HD083809Welch Foundation F-1895
6 · The paper itself

Abstract

Mammalian folate-dependent one-carbon (1C) metabolism provides the building blocks essential during development via amino acid interconversion, methyl-donor production, regeneration of redox factors, and de novo purine and thymidylate synthesis. Folate supplementation prevents many neural tube defects (NTDs) that occur during the embryonic process of neurulation. The mechanism by which folate functions during neurulation is not well understood, and not all NTDs are preventable by folate supplementation. Mthfd1l is a mitochondrial 1C metabolism enzyme that produces formate, a 1C donor that fuels biosynthesis and the methyl cycle in the cytoplasm. Homozygous deletion of the Mthfd1l gene in mice (Mthfd1l

Indexed as

AminohydrolasesAnimalsFormate-Tetrahydrofolate LigaseMethylenetetrahydrofolate Dehydrogenase (NADP)MiceMice, KnockoutMultienzyme ComplexesSpectrometry, Mass, Electrospray IonizationAminohydrolasesFormate-Tetrahydrofolate Ligaseformyl-methenyl-methylenetetrahydrofolate synthetaseMethylenetetrahydrofolate Dehydrogenase (NADP)Multienzyme ComplexesDESIFolateImaging mass spectrometryMetabolomicsMitochondrial metabolismMthfd1l

Identifiers

PMID33829277
OpenAlexW3140456446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.