Evidence map›Paper›PMID 33829245›Full record

ArticleThe American journal of clinical nutrition2021

Gut microbiota-derived metabolites and risk of coronary artery disease: a prospective study among US men and women.

Gang Liu, Jun Li, Yanping Li, Yang Hu, Adrian A Franke, Liming Liang, Frank B Hu, Andrew T Chan, Kenneth J Mukamal, Eric B Rimm and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Gang LiuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Jun LiDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-3519-8638
Yanping LiDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-0412-2748
Yang HuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-0200-5951
Adrian A FrankeDepartment of Food Science and Human Nutrition, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI, USA.
Liming LiangDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Frank B HuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Andrew T ChanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kenneth J MukamalBeth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Eric B RimmDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Qi SunDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USBroad Institute · USUniversity of Hawaiʻi at Mānoa · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Ultra-processed Foods, Diet Quality, and Cardiometabolic Health: An Inter-disciplinary Trans-Atlantic Collaborative ProjectR01DK120870 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Qibin Qi, Qi Sun · 2019 to 2026
$4.2M
PREMENOPAUSAL HORMONE LEVELS AND RISK OF BREAST CANCERU01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1996 to 2001
$1.1M
Chronic Inflammation and Type 2 Diabetes: A Multi-omics ApproachK99DK122128 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI LI, JUN · 2019 to 2021
$249k
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA176726NHLBI NIH HHS R01 HL035464NIDDK NIH HHS R01 DK120870NIH HHS CA67262
6 · The paper itself

Abstract

backgroundAccumulating evidence has suggested that human gut microbiota metabolize certain dietary compounds and subsequently produce bioactive metabolites that may exert beneficial or harmful effects on coronary artery disease (CAD) risk.

objectivesThis study examined the joint association of 2 gut microbiota metabolites, enterolactone and trimethylamine N-oxide (TMAO), that originate from intake of plant-based foods and animal products, respectively, in relation to CAD risk.

methodsA prospective nested case-control study of CAD was conducted among participants who were free of diabetes, cardiovascular disease, and cancer in the Nurses' Health Study II and the Health Professionals Follow-up Study. Plasma concentrations of enterolactone and TMAO, as well as choline and L-carnitine, were assayed among 608 CAD case-control pairs.

resultsA high enterolactone and low TMAO profile was associated with better diet quality, especially higher intake of whole grains and fiber and lower intake of red meats, as well as lower concentrations of plasma triglycerides and C-reactive protein. Participants with a high enterolactone/low TMAO profile had a significantly lower risk of CAD: the multivariate-adjusted OR was 0.58 (95% CI: 0.38, 0.90), compared with participants with a low enterolactone/high TMAO profile. No significant interaction between enterolactone and TMAO on CAD risk was observed. Neither TMAO nor enterolactone alone were associated with CAD risk in pooled analyses. In women, a higher enterolactone concentration was significantly associated with a 54% lower CAD risk (P trend = 0.03), although the interaction by sex was not significant.

conclusionsOur results show that a profile characterized by high enterolactone and low TMAO concentrations in plasma is linked to a healthful dietary pattern and significantly associated with a lower risk of CAD. Overall, these data suggest that, compared with individual markers, multiple microbiota-derived metabolites may facilitate better differentiation of CAD risk and characterization of the relations between diet, microbiota, and CAD risk.

Indexed as

Gastrointestinal Microbiome4-ButyrolactoneAdultCase-Control StudiesCoronary DiseaseDietFemaleHumansLignansMaleMethylaminesProspective StudiesRisk FactorsUnited States2,3-bis(3'-hydroxybenzyl)butyrolactone4-ButyrolactoneLignansMethylaminestrimethyloxaminecoronary artery diseaseepidemiologygut microbiotametabolitesprospective study

Identifiers

PMID33829245
PMCPMC8277432
OpenAlexW3148388466

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.