Evidence map›Paper›PMID 33829156›Full record

ArticleBrain communications2020

Meningeal blood-brain barrier disruption in acute traumatic brain injury.

Lisa Christine Turtzo, Neekita Jikaria, Martin R Cota, Joshua P Williford, Victoria Uche, Tara Davis, Judy MacLaren, Anita D Moses, Gunjan Parikh, Marcelo A Castro and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pathophysiology of chronic subdural hematoma-new insights.Therapeutic advances in neurological disorders · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Lisa Christine TurtzoAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-5617-4753
Neekita JikariaCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20814, USA.
Martin R CotaCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20814, USA.
Joshua P WillifordJohns Hopkins Suburban Hospital, Bethesda, MD 20814, USA.
Victoria UcheCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20814, USA.
Tara DavisJohns Hopkins Suburban Hospital, Bethesda, MD 20814, USA.ORCID 0000-0002-6293-3602
Judy MacLarenJohns Hopkins Suburban Hospital, Bethesda, MD 20814, USA.
Anita D MosesCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20814, USA.
Gunjan ParikhR Adams Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Marcelo A CastroCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20814, USA.
Dzung L PhamCenter for Neuroscience and Regenerative Medicine, Bethesda, MD 20814, USA.
John A ButmanRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Lawrence L LatourAcute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6160-5263
Center for Neuroscience and Regenerative Medicine · USSuburban Hospital · USNational Institutes of Health · USNational Institutes of Health Clinical Center · USUniformed Services University of the Health Sciences · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The meninges serve as a functional barrier surrounding the brain, critical to the immune response, and can be compromised following head trauma. Meningeal enhancement can be detected on contrast-enhanced MRI in patients presenting with acute traumatic brain injury, even when head CT is negative. Following head trauma, gadolinium-based contrast appears to extravasate from the vasculature, enhancing the dura within minutes, and later permeates the subarachnoid space. The aims of this study were to characterize the initial kinetics of the uptake of contrast agent after injury and the delayed redistribution of contrast enhancement in the subarachnoid space in hyperacute patients. Neuroimaging was obtained prospectively in two large ongoing observational studies of patients aged 18 years or older presenting to the emergency department with suspected acute head injury. Dynamic contrast-enhanced MRI studies in a cohort of consecutively enrolling patients with mild traumatic brain injury (

Indexed as

blood–brain barrierblood-cerebrospinal fluid barrierMRIneuroimagingtraumatic brain injury

Identifiers

PMID33829156
PMCPMC7869431
OpenAlexW3084302164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.