Evidence map›Paper›PMID 33829131›Full record

ArticleOne health outlook2020

Detection and genomic characterization of hepatitis E virus genotype 3 from pigs in Ghana, Africa.

Philip El-Duah, Dickson Dei, Tabea Binger, Augustina Sylverken, Robert Wollny, William Tasiame, Samuel Oppong, Yaw Adu-Sarkodie, Benjamin Emikpe, Raphael Folitse and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in One health outlook, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Philip El-DuahCharité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Dickson DeiGhana Veterinary Service, Kumasi, Ghana.
Tabea BingerKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Augustina SylverkenKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Robert WollnyInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
William TasiameCharité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Samuel OppongDepartment of Wildlife and Range Management, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Yaw Adu-SarkodieDepartment of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Benjamin EmikpeSchool of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Raphael FolitseSchool of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Jan Felix DrexlerCharité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Richard PhillipsKumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Christian DrostenCharité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Victor Max CormanCharité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Virology, Berlin, Germany.ORCID 0000-0002-3605-0136
Kwame Nkrumah University of Science and Technology · GHHumboldt-Universität zu Berlin · DEKumasi Centre for Collaborative Research in Tropical Medicine · GHUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis E virus (HEV) is a major cause of human hepatitis worldwide. Zoonotic genotypes of the virus have been found in diverse animal species with pigs playing a major role. Putative risk of zoonotic infection from livestock particularly swine in Sub-Saharan Africa including Ghana is poorly understood due to scarcity of available data, especially HEV sequence information.

methodsSerum samples were collected from cattle, sheep, goats and pigs from Kumasi in the Ashanti region of Ghana. Samples were subjected to nested RT-PCR screening and quantification of HEV RNA-positive samples using real-time RT-PCR and the World Health Organization International Standard for HEV. Testing of all pig samples for antibodies was done by ELISA. Sanger sequencing and genotyping was performed and one representative complete genome was generated to facilitate genome-wide comparison to other available African HEV sequences by phylogenetic analysis.

resultsA total of 420 samples were available from cattle (

conclusionHEV genotype 3 is highly endemic in pigs in Ghana and likely poses a zoonotic risk to people exposed to pigs. HEV genotype 3 in Ghana shares a common origin with other virus strains from Sub-Saharan Africa.

Indexed as

Foodborne diseasesInfectious disease reservoirsLivestockOne healthViral hepatitisZoonoses

Identifiers

PMID33829131
PMCPMC7993477
OpenAlexW3042529221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.