ArticleOne health outlook2019
Metagenomic discovery and co-infection of diverse wobbly possum disease viruses and a novel hepacivirus in Australian brushtail possums.
Article in One health outlook, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Lack of evidence for arthropod or vertical transmission of Hepacivirus bovis in a persistently infected dairy herd.Archives of virology · 2026Article
- Viral surveillance of invasive mammals in New Zealand reveals unique viral lineages reflecting their introduction history.Journal of virology · 2026Article
- Intraspecific variation of the hedgehog arteriviruses, which may constitute a new genus in the subfamily Heroarterivirinae of the family Arteriviridae.Archives of virology · 2025Article
- Identification of a Novel Hepacivirus in Southeast Asian Shrew (Pathogens (Basel, Switzerland) · 2023Article
- The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes.Nature communications · 2023Article
- Review
- Divergent hepaciviruses, delta-like viruses, and a chu-like virus in Australian marsupial carnivores (dasyurids).Virus evolution · 2023Article
- Molecular detection and genetic characterization of bovine hepacivirus identified in ticks collected from cattle in Harbin, northeastern China.Frontiers in veterinary science · 2023Article
- Article
- A Highly Divergent Hepacivirus Identified in Domestic Ducks Further Reveals the Genetic Diversity of Hepaciviruses.Viruses · 2022Article
- A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus.Viruses · 2021Article
- Molecular detection and genomic characterization of diverse hepaciviruses in African rodents.Virus evolution · 2021Article
- Virome composition in marine fish revealed by meta-transcriptomics.Virus evolution · 2021Article
- Novel hepaci- and pegi-like viruses in native Australian wildlife and non-human primates.Virus evolution · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAustralian brushtail possums (
methodsWe conducted a retrospective investigation to characterise WPD in native Australian brushtail possums, and used a bulk meta-transcriptomic approach (i.e. total RNA-sequencing) to investigate its potential viral aetiology. PCR assays were developed for case diagnosis and full genome recovery in the face of extensive genetic variation.
resultsWe identified genetically distinct lineages of arteriviruses from archival tissues of WPD-infected possums in Australia, termed wobbly possum disease virus AU1 and AU2. Phylogenetically, WPDV-AU1 and WPDV-AU2 shared only ~ 70% nucleotide similarity to each other and the WPDV-NZ strain, suggestive of a relatively ancient divergence. Notably, we also identified a novel and divergent hepacivirus (
conclusionsWe have identified marsupial-specific lineages of arteriviruses in mainland Australia that are genetically distinct from that in New Zealand, in some cases co-infecting animals with a novel hepacivirus. Our study provides new insight into the hidden genetic diversity of arteriviruses, the capacity for virus co-infection, and highlights the utility of meta-transcriptomics for disease investigation in a One Health context.
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