ArticleIEEE transactions on radiation and plasma medical sciences2019
Development of a Customizable Hepatic Arterial Tree and Particle Transport Model for Use in Treatment Planning.
Article in IEEE transactions on radiation and plasma medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Another hammer, but we need a wrench, and a screwdriver-positron emission tomography/magnetic resonance imaging represents another tool for post-delivery 90Y dosimetry, but what are we still missing?Journal of gastrointestinal oncology · 2024Article
- MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors.European journal of nuclear medicine and molecular imaging · 2024Article
- Intraprocedural C-arm dual-phase cone-beam enhancement patterns correlate with tumor absorbed dose after radioembolization.Medical physics · 2024Article
- Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue.Biophysical reviews · 2023Review
- A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals.EJNMMI physics · 2022Article
- Microspheres Used in Liver Radioembolization: From Conception to Clinical Effects.Molecules (Basel, Switzerland) · 2021Review
- A GPU-accelerated framework for rapid estimation of scanner-specific scatter in CT for virtual imaging trials.Physics in medicine and biology · 2021Article
- A proof-of-concept study of the in-vivo validation of a computational fluid dynamics model of personalized radioembolization.Scientific reports · 2021Article
- Multiscale Computational Fluid Dynamics Modeling for Personalized Liver Cancer Radioembolization Dosimetry.Journal of biomechanical engineering · 2021Article
- Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters.Frontiers in oncology · 2021Article
- Virtual clinical trials in medical imaging: a review.Journal of medical imaging (Bellingham, Wash.) · 2020Review
- Computational Modeling of the Liver Arterial Blood Flow for Microsphere Therapy: Effect of Boundary Conditions.Bioengineering (Basel, Switzerland) · 2020Article
- Personalized Dosimetry for Liver Cancer Y-90 Radioembolization Using Computational Fluid Dynamics and Monte Carlo Simulation.Annals of biomedical engineering · 2020Article
- Transarterial Radioembolization for Hepatocellular Carcinoma and Hepatic Metastases: Clinical Aspects and Dosimetry Models.Seminars in radiation oncology · 2020Review
- DukeSim: A Realistic, Rapid, and Scanner-Specific Simulation Framework in Computed Tomography.IEEE transactions on medical imaging · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Optimal treatment planning for radioembolization of hepatic cancers produces sufficient dose to tumors for control and dose to normal liver parenchyma that is below the threshold for toxicity. The non-uniform distribution of particles in liver microanatomy complicates the planning process as different functional regions receive different doses. Having realistic and patient-specific models of the arterial tree and microsphere trapping would be useful for developing more optimal treatment plans. We propose a macrocell-based growth method to generate models of the hepatic arterial tree from the proper hepatic artery to the terminal arterioles supplying the capillaries in the parenchyma. We show how these trees can be adapted to match patient values of pressure, flow, and vessel diameters while still conforming to laws controlling vessel bifurcation, changes in pressure, and blood flow. We also introduce a method to model particle transport within the tree that accounts for vessel and particle diameter distributions and show the non-uniform microsphere deposition pattern that results. Potential applications include investigating dose heterogeneity and microsphere deposition patterns.
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