Evidence map›Paper›PMID 33829078›Full record

ArticleRegenerative engineering and translational medicine2019

Biocompatibility and Viscoelastic Properties of Injectable Resilin-Like Polypeptide and Hyaluronan Hybrid Hydrogels in Rabbit Vocal Folds.

Renee E King, Hang Kuen Lau, Haiyan Zhang, Ishnoor Sidhu, Michael B Christensen, Eric W Fowler, Linqing Li, Xinqiao Jia, Kristi L Kiick, Susan L Thibeault

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative engineering and translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Renee E KingDivision of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, 5118 WIMR, 1111 Highland Ave, Madison, WI 53705-2275, USA.
Hang Kuen LauDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Haiyan ZhangDivision of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, 5118 WIMR, 1111 Highland Ave, Madison, WI 53705-2275, USA.
Ishnoor SidhuDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Michael B ChristensenThe National Center for Voice and Speech, University of Utah, 136 S Main St, Ste 320, Salt Lake City, UT 84101, USA.
Eric W FowlerDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Linqing LiDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Xinqiao JiaDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Kristi L KiickDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Susan L ThibeaultDivision of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, 5118 WIMR, 1111 Highland Ave, Madison, WI 53705-2275, USA.
University of Delaware · USUniversity of Wisconsin–Madison · USUniversity of Utah · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
University of Wisconsin Voice Research Training Program (T32)T32DC009401 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2009 to 2026
$6.3M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
COBRE on Membrane Protein Production and CharacterizationP30GM103519 · NIGMS · UNIVERSITY OF DELAWARE · PI LENHOFF, ABRAHAM M · 2012 to 2014
$3.3M
Highly resilient, hydrophilic bioelastomers for engineering vocal fold tissueR01DC011377 · NIDCD · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L · 2012 to 2016
$2.3M
NIDCD NIH HHS R01 DC011377NIDCD NIH HHS T32 DC009401NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM103519NIGMS NIH HHS P30 GM110758
6 · The paper itself

Abstract

Vocal fold scar, characterized by alterations in the lamina propria extracellular matrix, disrupts normal voice quality and function. Due to a lack of satisfactory clinical treatments, there is a need for tissue engineering strategies to restore voice. Candidate biomaterials for vocal fold tissue engineering must match the unique biomechanical and viscoelastic properties of native tissue without provoking inflammation. We sought to introduce elastomeric properties to hyaluronic acid (HA)-based biomaterials by incorporating resilin-like polypeptide (RLP) into hybrid hydrogels. Physically crosslinked RLP/HA and chemically crosslinked RLP-acrylamide/thiolated HA (RLP-AM/HA-SH) hydrogels were fabricated using cytocompatible chemistries. Mechanical properties of hydrogels were assessed in vitro using oscillatory rheology. Hybrid hydrogels were injected into rabbit vocal folds and tissues were assessed using rheology and histology. A small number of animals underwent acute vocal fold injury followed by injection of RLP-AM/HA-SH hydrogel alone or as a carrier for human bone marrow mesenchymal stem cells (BM-MSCs). Rheological testing confirmed that mechanical properties of materials in vitro resembled native vocal fold tissue and that viscoelasticity of vocal fold mucosa was preserved days 5 and 21 after injection. Histological analysis revealed that hybrid hydrogels provoked only mild inflammation in vocal fold lamina propria with demonstrated safety in the airway for up to 3 weeks, confirming acute biocompatibility of crosslinking chemistries. After acute injury, RLP-AM/HA-SH gel with and without BM-MSCs did not result in adverse effects or increased inflammation. Collectively, results indicate that RLP and HA-based hybrid hydrogels are highly promising for engineering the vocal fold lamina propria.

Indexed as

BiocompatibilityInjectable hydrogelsResilinViscoelastic propertiesVocal folds

Identifiers

PMID33829078
PMCPMC8022864
OpenAlexW2919068168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.