Evidence map›Paper›PMID 33829000›Full record

ArticleFrontiers in cellular and infection microbiology2021

Subunit Vaccine ESAT-6:c-di-AMP Delivered by Intranasal Route Elicits Immune Responses and Protects Against

Huanhuan Ning, Wei Zhang, Jian Kang, Tianbing Ding, Xuan Liang, Yanzhi Lu, Chengxuan Guo, Wenjie Sun, Huapeng Wang, Yinlan Bai and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Antigen 85B ofVaccines · 2026
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  13. Ag85B with c-di-AMP as mucosal adjuvant showed immunotherapeutic effects on persistent Mycobacterium tuberculosis infection in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Huanhuan NingKey Laboratory of Resources Biology and Biotechnology in Western China, College of Life Sciences, Northwest University, Xi'an, China.
Wei ZhangDepartment of Paediatrics, TangDu Hospital, Air Force Medical University, Xi'an, China.
Jian KangDepartment of Microbiology and Pathogen Biology, Basic Medical School, Air Force Medical University, Xi'an, China.
Tianbing DingMedical College, Xijing University, Xi'an, China.
Xuan LiangKey Laboratory of Resources Biology and Biotechnology in Western China, College of Life Sciences, Northwest University, Xi'an, China.
Yanzhi LuDepartment of Microbiology and Pathogen Biology, Basic Medical School, Air Force Medical University, Xi'an, China.
Chengxuan GuoStudent Brigade, Basic Medical School, Air Force Medical University, Xi'an, China.
Wenjie SunStudent Brigade, Basic Medical School, Air Force Medical University, Xi'an, China.
Huapeng WangStudent Brigade, Basic Medical School, Air Force Medical University, Xi'an, China.
Yinlan BaiDepartment of Microbiology and Pathogen Biology, Basic Medical School, Air Force Medical University, Xi'an, China.
Lixin ShenKey Laboratory of Resources Biology and Biotechnology in Western China, College of Life Sciences, Northwest University, Xi'an, China.
Air Force Medical University · CNNorthwest University · CNXijing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Indexed as

Mycobacterium tuberculosisTuberculosisTuberculosis VaccinesAnimalsAntigens, BacterialBacterial ProteinsCD8-Positive T-LymphocytesDinucleoside PhosphatesImmunityMiceVaccines, SubunitAntigens, BacterialBacterial Proteinscyclic diadenosine phosphateDinucleoside PhosphatesTuberculosis VaccinesVaccines, Subunitc-di-AMPESAT-6mucosal adjuvantMycobacterium tuberculosissubunit vaccine

Identifiers

PMID33829000
PMCPMC8019782
OpenAlexW3136738543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.