ArticleFrontiers in cellular and infection microbiology2021
The Oral Microbiome in Periodontal Health.
Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Bacteria of healthy periodontal tissues as candidates of probiotics: a systematic review.European journal of medical research · 2024Pooled it
- A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function.Scientific reports · 2025Trial
- Trial
- Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression.Journal of clinical periodontology · 2026Observational
- Oral Microbiome Signatures in Indonesian Healthy, Gingivitis, and Periodontitis Subjects: A 16S rRNA Next-Generation Sequencing Analysis-Based Exploratory Study.Dentistry journal · 2026Article
- Subgingival Microbiota Shifts Following Diode Laser-Activated Indocyanine Green Treatment in Periodontitis: A Pilot 16S rDNA Study.Microorganisms · 2026Article
- Comparative microbiome profiling of betel quid chewers and non-chewers to identify dysbiotic microbial signatures.Scientific reports · 2026Article
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- The Oral Microbiome Is a Population-Scale Readout of the Exposome, Age, and Systemic Health.bioRxiv : the preprint server for biology · 2026Article
- Characterization of the oral microbiome in the diverse South African population by PacBio HiFi sequencing.Applied microbiology and biotechnology · 2026Article
- Salivary microbial profiles across periodontal severity stage according to the 2018 AAP/EFP classifications: a cross-sectional study.Frontiers in oral health · 2026Article
- The subgingival microbiome in periodontitis: from ecological dysbiosis and metabolic reprogramming to precision interventions.Frontiers in microbiology · 2026Review
- Oral microbiota alterations in radiographic axial spondyloarthritis.Frontiers in medicine · 2026Article
- The cross-talk between T and B lymphocytes and the oral microbiome in health and disease: a narrative review.Frontiers in immunology · 2026Review
- Inhibitory Effect ofInternational journal of nanomedicine · 2026Article
- Lesion-specific oral microbiome signatures and predicted carcinogenic pathways in oral squamous cell carcinoma: a paired-site study in Pakistan.Journal of oral microbiology · 2026Article
- Unveiling potential driver taxa in subgingival plaque and their roles in mediating periodontitis progression.Journal of oral microbiology · 2026Article
- Survival implications of the age-associated tumor and normal adjacent tissue microbiome among colorectal cancer patients.Gut pathogens · 2025Article
- In-Depth Multi-Approach Analysis of WGS Metagenomics Data Reveals Signatures Potentially Explaining Features in Periodontitis Stage Severity.Dentistry journal · 2025Article
- Assessing the Oral Microbiome in Women of Reproductive Age: A Narrative Review.Clinics and practice · 2025Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained image of "healthy OM" can be distorted.To overcome this bias, we taxonomically characterized the OM in almost a hundred young students of dentistry with precise oral hygiene and no signs of periodontal disease. We compared the results with the OM composition of older periodontally healthy individuals and also a group of patients with severe periodontitis (aggressive periodontitis according to former classification system). The clustering analysis revealed not only two compact clearly separated clusters corresponding to each state of health, but also a group of samples forming an overlap between both well-pronounced states. Additionally, in the cluster of periodontally healthy samples, few outliers with atypical OM and two major stomatotypes could be distinguished, differing in the prevalence and relative abundance of two main bacterial genera:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.