ArticleJournal of ophthalmology2021
Histopathological Variability and Concomitant Lesions in Pterygium in a Large Case Series.
Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Genome-Wide Association Study of Pterygium Versus Pinguecula Identifies Loci Associated with Lesion-Type Divergence.Ophthalmology science · 2026Article
- Malignant melanocytic lesions in clinically suspected pterygium.The British journal of ophthalmology · 2026Article
- Epidemiological investigative report on ocular morbidity in children in rural Kenya.International journal of ophthalmology · 2026Article
- TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy.Investigative ophthalmology & visual science · 2025Article
- Correlation of histopathological features and clinical findings in pterygium.Bioinformation · 2025Article
- Key Clinical and Histopathological Features of a Pterygium-Like Induced Lesion in a Rabbit Model.Translational vision science & technology · 2024Article
- Comment on: 'Prevalence of co-existent neoplasia in clinically diagnosed pterygia in a UK population'.Eye (London, England) · 2024Article
- Prevalence of co-existent neoplasia in clinically diagnosed pterygia in a UK population.Eye (London, England) · 2023Article
- Dendritic Melanocytic Hyperplasia in Pterygia: A Potential Source of Diagnostic Confusion with Primary Acquired Melanosis.Ocular oncology and pathology · 2023Article
- Resveratrol inhibits TGF-β1-induced fibrotic effects in human pterygium fibroblasts.Environmental health and preventive medicine · 2023Article
- Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pterygium is a common lesion consisting of fleshy conjunctival growth extending towards the cornea. There is no documented risk of malignant transformation; however, concomitant disease is not rare, and its link to sunlight exposure indicates a risk of other malignancies. The purpose of our study is to describe histopathological features of resected pterygiums and to recognize patients at risk of other conjunctival diseases. One hundred and forty-nine formalin-fixed and paraffin-embedded pterygium samples were subjected to histopathological analysis. Histological H&E sections were obtained and digitalized using a Zeiss Axio Scan.Z1 slide scanner. Thirteen predefined morphological features were used to record histopathological changes in the epithelium and substantia propria. Neovascularization was observed in 54% of the samples. Sun damage, comprising solar elastosis and stromal plaque, was present in 81% of the samples. Variation in epithelial thickness was the most common change, with acanthosis and atrophy being observed in 62% and 26% of the samples, respectively. In our series, 21% (31/149) of pterygiums showed mild to moderate dysplasia, a finding that may be associated to ocular surface squamous neoplasia (OSSN). Moreover, 32% (47/149) of the cases showed melanocytic hyperplasia, which could represent primary acquired melanosis (PAM). There is a positive correlation between dysplasia and chronic inflammation (
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Registered trials
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