ArticleResearch in pharmaceutical sciences2020
A simple and validated HPLC method for vancomycin assay in plasma samples: the necessity of TDM center development in Southern Iran.
Article in Research in pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Advanced Biosensing Strategies for Last-Line Antibiotics Vancomycin, Colistin, Daptomycin and Meropenem: Comparative Analysis of Electrochemical and Optical Detection Methods.Antibiotics (Basel, Switzerland) · 2026Article
- A one-shot approach for serum vancomycin assessment using fluorescence-based molecularly imprinted polymer nanoparticles.Mikrochimica acta · 2026Article
- Therapeutic vancomycin monitoring: a comparative analysis of high-performance liquid chromatography and chemiluminescent microparticle immunoassay methods in liver transplant recipients.Frontiers in pharmacology · 2025Article
- Assay Interference Causing Persistently Elevated Vancomycin Levels Leading to Treatment Failure and Fatal Outcome.Cureus · 2024Article
- One-Step Detection of Vancomycin in Whole Blood Using the Lateral Flow Immunoassay.Biosensors · 2024Article
- Development and validation of a new robust RP-HPLC method for simultaneous quantitation of insulin and pramlintide in non-invasive and smart glucose-responsive microparticles.Research in pharmaceutical sciences · 2022Article
- An Overview of Analytical Methodologies for Determination of Vancomycin in Human Plasma.Molecules (Basel, Switzerland) · 2022Review
- Preparation of Vancomycin-Loaded Aerogels Implementing Inkjet Printing and Superhydrophobic Surfaces.Gels (Basel, Switzerland) · 2022Article
- Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters.Frontiers in pharmacology · 2022Article
- Risk Scoring System for Vancomycin-Associated Acute Kidney Injury.Frontiers in pharmacology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeVancomycin is a glycopeptide antibiotic which is the drug of choice against methicillin-resistant EXPERIMENTAL APPROACH: In this study, a brief review of different parameters and variables which could affect the sensitivity, selectivity of the validated HPLC method for vancomycin determination were considered. According to the previous studies a simple, fast, and the relatively low-cost method was established for vancomycin determination in plasma samples. FINDINGS/
resultsThe developed HPLC assay indicated a calibration curve with R-square of > 0.999, acceptable selectivity, the accuracy of 90-105%, CV% of less than 15%, the limit of quantification of 1 μg/mL, and limit of detection of 300 ng/mL. Vancomycin trough level, the area under the curve, renal clearance, the volume of distribution, and elimination constant were measured in patients using this validated method. CONCLUSION AND IMPLICATIONS: Validated method for assay of vancomycin plasma levels was used to quantify vancomycin levels of four patients who were admitted to the ICU of Nemazee Hospital. According to the results, two of these patients showed lower levels than recommended therapeutic purposes while one of them showed a toxic level. According to the results, the TDM assessment of vancomycin is strongly recommended for patients who are hospitalized in ICU.
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