Evidence map›Paper›PMID 33828453›Full record

ReviewFrontiers in neuroscience2021

Mapping Network Activity in Sleep.

Priyattam J Shiromani, Carlos Blanco-Centurion, Aurelio Vidal-Ortiz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of the Locus Coeruleus Arousal Promoting Neurons in Maintaining Brain Criticality across the Sleep-Wake Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Priyattam J ShiromaniRalph H. Johnson VA Medical Center, Charleston, SC, United States.
Carlos Blanco-CenturionDepartment of Psychiatry and Biobehavioral Science, Medical University of South Carolina, Charleston, SC, United States.
Aurelio Vidal-OrtizRalph H. Johnson VA Medical Center, Charleston, SC, United States.
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

Melanin Concentrating Hormone Neurons in SleepR01NS052287 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2006 to 2018
$3.4M
Sleep Neurobiology and CircuitryI01BX000798 · VA · VA BOSTON HEALTH CARE SYSTEM · PI HOWARD C. BECKER · 2011 to 2026
–
BLRD VA I01 BX000798NINDS NIH HHS R01 NS052287
6 · The paper itself

Abstract

It was in the influenza pandemic of 1918 that von Economo identified specific brain regions regulating sleep and wake. Since then researchers have used a variety of tools to determine how the brain shifts between states of consciousness. In every enterprise new tools have validated existing data, corrected errors and made new discoveries to advance science. The brain is a challenge but new tools can disentangle the brain network. We summarize the newest tool, a miniature microscope, that provides unprecedented view of activity of glia and neurons in freely behaving mice. With this tool we have observed that the activity of a majority of GABA and MCH neurons in the lateral hypothalamus is heavily biased toward sleep. We suggest that miniscope data identifies activity at the cellular level in normal versus diseased brains, and also in response to specific hypnotics. Shifts in activity in small networks across the brain will help identify point of criticality that switches the brain from wake to sleep.

Indexed as

brain networkscalcium imaginghypothalamusmicroendoscopysleep

Identifiers

PMID33828453
PMCPMC8019804
OpenAlexW3138901962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.