Evidence map›Paper›PMID 33828452›Full record

ArticleFrontiers in neuroscience2021

Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders.

Zhihong Lan, Shoujun Xu, Yunfan Wu, Likun Xia, Kelei Hua, Meng Li, Mengchen Liu, Yi Yin, Chunlong Li, Shumei Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  7. mGNN-bw: Multi-Scale Graph Neural Network Based on Biased Random Walk Path Aggregation for ASD Diagnosis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Zhihong LanDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Shoujun XuDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, China.
Yunfan WuDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Likun XiaDepartment of Magnetic Resonance Imaging, People's Hospital of Yuxi City, Yuxi, China.
Kelei HuaDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Meng LiDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Mengchen LiuDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Yi YinDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Chunlong LiDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Shumei HuangDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Ying FengDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Guihua JiangDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Tianyue WangDepartment of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Guangdong Provincial People's Hospital · CNKunming Medical University · CNShenzhen Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe study was aimed at investigating the alterations of local spontaneous brain activity in preschool boys with autism spectrum disorders (ASD).

methodsBased on regional homogeneity (ReHo), the acquired resting state functional magnetic resonance imaging (fMRI) data sets, which included 86 boys with ASD and 54 typically developing (TD) boys, were used to detect regional brain activity. Pearson correlation analysis was used to study the relationship between abnormal ReHo value and the Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC), developmental quotient, and age.

resultsIn the ASD group, we found increased ReHo in the right calcarine as well as decreased ReHo in the opercular part of the left inferior frontal gyrus, the left middle temporal gyrus, the left angular gyrus, and the right medial orbital frontal cortex (

conclusionsOur study found spontaneous activity changes in multiple brain regions, especially the visual and language-related areas of ASD, that may help to further understand the clinical characteristics of boys with ASD.

Indexed as

autism spectrum disordersneural activitypreschool boysregional homogeneityresting-state fMRI

Identifiers

PMID33828452
PMCPMC8019812
OpenAlexW3137217861

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.