ArticleFrontiers in neuroscience2021
Changes in Degree Centrality of Network Nodes in Different Frequency Bands in Parkinson's Disease With Depression and Without Depression.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Frequency-dependent alterations of degree centrality in patients with poststroke depression: a resting-state functional MRI study.Neuroreport · 2026Article
- Energetic implications of fMRI-based nodal complex network metrics: a complex picture unfolds across diverse brain states.bioRxiv : the preprint server for biology · 2026Article
- An exploratory study of altered regional homogeneity in Parkinson's disease with depression.Frontiers in psychiatry · 2026Article
- Altered cerebral perfusion in Parkinson's disease patients with anxiety: an arterial spin labeling MRI study.Frontiers in neurology · 2025Article
- Distance-related functional reorganization predicts motor outcome in stroke patients.BMC medicine · 2024Observational
- Atrophy patterns in hippocampus and amygdala subregions of depressed patients with Parkinson's disease.Brain imaging and behavior · 2024Article
- Frequency specific alterations of the degree centrality in patients with acute basal ganglia ischemic stroke: a resting-state fMRI study.Brain imaging and behavior · 2024Article
- Hippocampal volume and resting-state functional connectivity on magnetic resonance imaging in patients with Parkinson and depression.Quantitative imaging in medicine and surgery · 2024Article
- Regions with Altered Degree Centrality and Their Functional Connectivity in First-Episode Drug-Naïve Major Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study.Alpha psychiatry · 2023Article
- Altered functional connectivity density and structural covariance networks in women with premenstrual syndrome.Quantitative imaging in medicine and surgery · 2023Article
- Altered Fractional Amplitude of Low-Frequency Fluctuation in Anxious Parkinson's Disease.Brain sciences · 2023Article
- Altered brain spontaneous activity in patients with cerebral small vessel disease using the amplitude of low-frequency fluctuation of different frequency bands.Frontiers in neuroscience · 2023Article
- Functional and structural alterations as diagnostic imaging markers for depression inFrontiers in neuroscience · 2023Article
- Peripheral Interleukin-18 is negatively correlated with abnormal brain activity in patients with depression: a resting-state fMRI study.BMC psychiatry · 2022Article
- Frequency-dependent functional alterations in people living with HIV with early stage of HIV-associated neurocognitive disorder.Frontiers in neuroscience · 2022Article
- Alterations of degree centrality and functional connectivity in classic trigeminal neuralgia.Frontiers in neuroscience · 2022Article
- Altered Long- and Short-Range Functional Connectivity Density in Patients With Thyroid-Associated Ophthalmopathy: A Resting-State fMRI Study.Frontiers in neurology · 2022Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression induces an early onset of Parkinson's disease (PD), aggravates dyskinesia and cognitive impairment, and accelerates disease progression. However, it is very difficult to identify and diagnose PD with depression (PDD) in the early clinical stage. Few studies have suggested that the changes in neural networks are associated with PDD, while degree centrality (DC) has been documented to be effective in detecting brain network changes.
objectivesThe objectives of this study are to explore DC changes between patients with PDD and without depression (PDND) and to find the key brain hubs involved with depression in PD patients.
methodsOne hundred and four PD patients and 54 healthy controls (HCs) underwent brain resting-state functional magnetic resonance imaging. The Data Processing and Analysis of Brain Imaging and Resting-State Functional Magnetic Resonance Data Analysis Toolkit were used for processing and statistical analysis. The DC value of each frequency band was calculated. One-way analysis of variance and a two-sample
resultsThe DC value of different brain regions changed in PDD and PDND in different frequency bands. The prefrontal lobe, limbic system, and basal ganglia were the main brain regions involved. PDD patients showed a wider range and more abnormal brain areas in the slow-4 frequency band (0.027-0.073 Hz) compared to the HCs. PDD showed a decreased DC value in the medial frontal gyrus, bilateral cuneus gyrus, right lingual gyrus, bilateral supplementary motor area (SMA), bilateral superior frontal gyrus, and left paracentral lobule, but an increased DC value in the bilateral brainstem, midbrain, bilateral parahippocampal gyrus, cerebellum, left superior temporal gyrus, bilateral insula, left fusiform gyrus, and left caudate nucleus in the traditional frequency band (0.01-0.08 Hz) compared to PDND patients. PDND patients displayed more abnormal functions in the basal ganglia in the slow-4 frequency band.
conclusionThe DC changes in PDD and PDND are frequency dependent and frequency specific. The medial frontal gyrus, SMA, and limbic system may be the key hubs for depression in PD.
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