Evidence map›Paper›PMID 33828397›Full record

SynthesisWorld journal of gastroenterology2021

Hepatitis E in solid organ transplant recipients: A systematic review and meta-analysis.

Panupong Hansrivijit, Angkawipa Trongtorsak, Max M Puthenpura, Boonphiphop Boonpheng, Charat Thongprayoon, Karn Wijarnpreecha, Avishek Choudhury, Wisit Kaewput, Shennen A Mao, Michael A Mao and 2 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Donor-derived viral infections: the usual suspects and the new kids on the block.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  11. Article
  12. Differential miRNA signatures in Hepatitis E Virus Infection: Insights into acute, chronic, and pregnancy-related outcomes.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Panupong HansrivijitDepartment of Internal Medicine, UPMC Pinnacle, Harrisburg, PA 17104, United States.
Angkawipa TrongtorsakDepartment of Internal Medicine, Amita Health Saint Francis Hospital, Evanston, IL 60202, United States.
Max M PuthenpuraDepartment of Medicine, Drexel University College of Medicine, Philadelphia, PA 19129, United States.
Boonphiphop BoonphengDavid Geffen School of Medicine, University of California, Los Angeles, Division of Nephrology, Los Angeles, CA 90095, United States.
Charat ThongprayoonDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, United States.
Karn WijarnpreechaDepartment of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, United States.
Avishek ChoudhurySchool of Systems and Enterprises, Stevens Institute of Technology, Hoboken, NJ 07030, United States.
Wisit KaewputDepartment of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
Shennen A MaoDepartment of Transplant Surgery, Mayo Clinic, Jacksonville, FL 32224, United States.
Michael A MaoDepartment of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL 32224, United States.
Caroline C JadlowiecDepartment of Transplant Center, Mayo Clinic, Scottsdale, AZ 85259, United States.
Wisit CheungpasitpornDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, United States. wcheungpasitporn@gmail.com.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USPhramongkutklao College of MedicineStevens Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis E virus (HEV) infection is underdiagnosed due to the use of serological assays with low sensitivity. Although most patients with HEV recover completely, HEV infection among patients with pre-existing chronic liver disease and organ-transplant recipients on immunosuppressive therapy can result in decompensated liver disease and death.

aimTo demonstrate the prevalence of HEV infection in solid organ transplant (SOT) recipients.

methodsWe searched Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible articles through October 2020. The inclusion criteria consisted of adult patients with history of SOT. HEV infection is confirmed by either HEV-immunoglobulin G, HEV-immunoglobulin M, or HEV RNA assay.

resultsOf 563 citations, a total of 22 studies (

conclusionHEV infection is common in SOT recipients, particularly in middle-income countries. The prevalence of HEV infection in lung transplant recipients is considerably less common than other organ transplants. More studies examining the clinical impacts of HEV infection in SOT recipients, such as graft failure, rejection, and mortality are warranted.

Indexed as

Hepatitis EHepatitis E virusOrgan TransplantationAdultHumansRNA, ViralTransplant RecipientsRNA, ViralHepatitis E virusHepatitis E virus infectionPrevalenceSolid organ transplant

Identifiers

PMID33828397
PMCPMC8006097
OpenAlexW3147970157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.