ArticleNature2021
CAR directs T cell adaptation to bile acids in the small intestine.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 81 citations in OpenAlex.
- The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.Gut microbes · 2026Review
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Microbiota-gut-brain axis and bile acids-driven neuromodulation.Neural regeneration research · 2026Article
- Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy.Cancer cell · 2026Article
- Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology.JCI insight · 2026Article
- Integrating bile acid metabolism into precision nutrition strategies for improved swine performance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity.Journal of advanced research · 2026Review
- Engineering Tfh-Specific Nanoadjuvant to Counteract Bile Acid-Induced Mitophagy and Vaccine Hyporesponsivenes.Theranostics · 2026Article
- Psychological stress and gut microbiota regulation of osteoarthritis progression: mechanisms and therapeutic strategies.Frontiers in microbiology · 2026Review
- Microbial transformation of secondary bile acids: roles in gut ecology and autoimmune diseases.Frontiers in immunology · 2026Review
- Gut microbiota and bile acid profiles in purebred vs. crossbred sows: links to oxidative stress and inflammation in late gestation.Microbial genomics · 2025Article
- Review
- The Effect of Gut Microbiome Perturbation on the Bioavailability of Glycyrrhizic Acid in Rats.Pharmaceutics · 2025Article
- Molecules-mediated bidirectional interactions between microbes and human cells.NPJ biofilms and microbiomes · 2025Review
- Bile acids and their receptors in hepatic immunity.Liver research (Beijing, China) · 2025Review
- An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.Nature communications · 2025Article
- Fungi and cancer: unveiling the complex role of fungal infections in tumor biology and therapeutic resistance.Frontiers in cellular and infection microbiology · 2025Review
- HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis.Frontiers in immunology · 2025Article
- Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment.Biomedicines · 2024Review
- Unlocking gut-liver-brain axis communication metabolites: energy metabolism, immunity and barriers.NPJ biofilms and microbiomes · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 4 institutions in 2 countries.
Mei Lan Chen *Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Xiangsheng Huang *Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Hongtao WangSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Courtney HegnerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Yujin LiuDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Jinsai ShangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL, USA.
Amber EliasonDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.ORCID http://orcid.org/0000-0001-8765-686X
Huitian DiaoDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
HaJeung ParkX-ray Crystallography Core Facility, The Scripps Research Institute, Jupiter, FL, USA.
Blake FreyDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Guohui WangSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Sarah A MosureDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Laura A SoltDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.ORCID http://orcid.org/0000-0001-8807-0342
Douglas J KojetinThe Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL, USA.ORCID http://orcid.org/0000-0001-8058-6168
Alex Rodriguez-PalaciosDivision of Gastroenterology and Liver Disease, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Deborah A SchadyDepartment of Pathology and Immunology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Casey T WeaverDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Matthew E PipkinDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
David D MooreDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. daviddmoore@berkeley.edu.ORCID http://orcid.org/0000-0002-5151-9748
Mark S SundrudDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA. msundrud@scripps.edu.ORCID http://orcid.org/0000-0002-4249-0525
Scripps Research Institute · USBaylor College of Medicine · USUniversity of Alabama at Birmingham · USUniversity Hospitals of Cleveland · US
Funding
Transcription factor regulation of CD4 and CD8 T cell effector and memory differentiation and functionP01AI145815 · NIAID · UNIVERSITY OF FLORIDA · PI PIPKIN, MATTHEW EUGENE · 2020 to 2024
$11.0MTF regulation of CD8 and CD4 T cell memory in both systemic and dermal infectionU19AI109976 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN · 2014 to 2018
$10.5MTraining Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6MSpecialization of Innate and Adaptive Immune Cells in Intestinal Barrier FunctionR01DK113789 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEAVER, CASEY T · 2017 to 2021
$2.3MBile acid-dependent T cell regulation in the intestineR01AI143821 · NIAID · UNIVERSITY OF FLORIDA · PI SUNDRUD, MARK SCOTT · 2019 to 2023
$2.2MTranscriptional control of Intestinal CD4+ T cell adaptionR21AI119728 · NIAID · SCRIPPS FLORIDA · PI SUNDRUD, MARK SCOTT · 2015 to 2016
$528kControl of Colitogenic Th17 cells by Vitamin D Receptor SignalingF30DK127865 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FREY, BLAKE · 2021 to 2024
$171kNIAID NIH HHS P01 AI145815NIAID NIH HHS R01 AI143821NIAID NIH HHS R21 AI119728NIAID NIH HHS U19 AI109976NIAMS NIH HHS T32 AR069516NIDDK NIH HHS F30 DK127865NIDDK NIH HHS R01 DK113789NIH HHS R01 AI118931
Abstract
Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine
Indexed as
Gene Expression RegulationAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Bile Acids and SaltsCD4-Positive T-LymphocytesConstitutive Androstane ReceptorCrohn DiseaseFemaleIleitisInflammationInterleukin-10Intestine, SmallMiceReceptors, Cytoplasmic and NuclearT-LymphocytesATP Binding Cassette Transporter, Subfamily B, Member 1Bile Acids and SaltsConstitutive Androstane ReceptorInterleukin-10Nr1i3 protein, mouseReceptors, Cytoplasmic and Nuclear
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.