Evidence map›Paper›PMID 33828299›Full record

ArticleNature2021

Type III-A CRISPR immunity promotes mutagenesis of staphylococci.

Charlie Y Mo, Jacob Mathai, Jakob T Rostøl, Andrew Varble, Dalton V Banh, Luciano A Marraffini

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  4. Cas9 modulatesMicrobiology (Reading, England) · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. mLife · 2024
    Review
  10. Review
  11. Article
  12. Defense and anti-defense mechanisms of bacteria and bacteriophages.Journal of Zhejiang University. Science. B · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Charlie Y MoLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA. cmo@rockefeller.edu.ORCID http://orcid.org/0000-0003-4378-8021
Jacob MathaiLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA.
Jakob T RostølLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA.
Andrew VarbleLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA.
Dalton V BanhLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-8167-9358
Luciano A MarraffiniLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA. marraffini@rockefeller.edu.ORCID http://orcid.org/0000-0002-9163-0969
Rockefeller University · USCornell University · USHoward Hughes Medical Institute · US

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Generation of immunological memory by CRISPR-Cas systemsDP1GM128184 · NIGMS · ROCKEFELLER UNIVERSITY · PI MARRAFFINI, LUCIANO A · 2017 to 2021
$5.9M
Elucidating how CRISPR-Cas Modulates the Spread of S. aureus Pathogenicity IslandsF30AI157535 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BANH, DALTON VAN · 2021 to 2024
$203k
Biochemical and cellular DNA targeting by the type III-A CRISPR-Cas systemF32GM128271 · NIGMS · ROCKEFELLER UNIVERSITY · PI MO, CHARLIE YE · 2018 to 2019
$120k
NIAID NIH HHS F30 AI157535NIGMS NIH HHS DP1 GM128184NIGMS NIH HHS F32 GM128271NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Horizontal gene transfer and mutation are the two major drivers of microbial evolution that enable bacteria to adapt to fluctuating environmental stressors

Indexed as

MutagenesisMutationAnti-Bacterial AgentsBacteriophagesCRISPR-Associated ProteinsCRISPR-Cas SystemsDeoxyribonucleasesDNA, Single-StrandedDrug Resistance, MicrobialSOS Response, GeneticsStaphylococcusStaphylococcus aureusStaphylococcus epidermidisTime FactorsAnti-Bacterial AgentsCRISPR-Associated ProteinsDeoxyribonucleasesDNA, Single-Stranded

Identifiers

PMID33828299
PMCPMC8820005
OpenAlexW3142284439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.