ArticleNature2021
The structure, function and evolution of a complete human chromosome 8.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers.
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228citing papers in PubMed
77.7field-weighted citation impact, top 1% of its field
What it found
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Who cites it
228 citing papers in PubMed, 371 citations in OpenAlex.
- Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026Review
- Optimized Genome-Wide Profiling of Centromeric Chromatin Complexes by ChIP-seq.Current protocols · 2026Article
- Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome.Cell genomics · 2026Article
- Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and chromosome missegregation.Cell reports · 2026Article
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- HPRC2: A human pangenome reference with near-complete coverage of common genetic variation.bioRxiv : the preprint server for biology · 2026Article
- Germline hypomethylation shapes dynamic CpG reservoirs in ape genomes.bioRxiv : the preprint server for biology · 2026Article
- Complete chromosome 21 centromere sequencing of families with Down syndrome.American journal of human genetics · 2026Article
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- HOROSCOPE: Decoding human centromere architecture from short reads usingbioRxiv : the preprint server for biology · 2026Article
- Centromeric tandem repeats expansions in plateau zokor enhance chromosome stability for high-altitude adaptation.Genome biology · 2026Article
- Toward telomere-to-telomere genomics in Fabaceae: Unlocking comparative and functional insights into symbiotic nitrogen fixation.Cell genomics · 2026Review
- Accessing medically relevant complex regions with a pangenome graph of 20 near-complete Japanese haplotypes.Nature communications · 2026Article
- Models for the architecture of the human inner kinetochore on centromeric α-satellite CENP-A nucleosome arrays.Nature communications · 2026Article
- A complete human pancreatic cancer genome.bioRxiv : the preprint server for biology · 2026Article
- A genomic and epigenomic view of human centromeres.Nature reviews. Genetics · 2026Review
- Haplotype-resolved genome assemblies of BJ and IMR-90 human fibroblast cell lines reveal extensive structural variation and enable reanalysis of historical sequencing data.Nucleic acids research · 2026Article
- A segmental duplication-mediated deletion leads to neocentromere formation in orangutans.bioRxiv : the preprint server for biology · 2026Article
- Haplotype-resolved centromeric chromatin organization from a complete diploid human genome.bioRxiv : the preprint server for biology · 2026Article
168 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 11 institutions in 3 countries.
Glennis A LogsdonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2396-0656
Mitchell R VollgerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8651-1615
PingHsun HsiehDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Yafei MaoDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9648-4278
Mikhail A LiskovykhDevelopmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA.
Sergey KorenGenome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1472-8962
Sergey NurkGenome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Ludovica MercuriDepartment of Biology, University of Bari, Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0002-3688-4501
Philip C DishuckDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2223-9787
Arang RhieGenome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9809-8127
Leonardo G de LimaStowers Institute for Medical Research, Kansas City, MO, USA.ORCID http://orcid.org/0000-0001-6340-6065
Tatiana DvorkinaCenter for Algorithmic Biotechnology, Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.
David PorubskyDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8414-8966
William T HarveyDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Alla MikheenkoCenter for Algorithmic Biotechnology, Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.
Andrey V BzikadzeGraduate Program in Bioinformatics and Systems Biology, University of California, San Diego, San Diego, CA, USA.
Milinn KremitzkiMcDonnell Genome Institute, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.
Tina A Graves-LindsayMcDonnell Genome Institute, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.
Chirag JainGenome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Kendra HoekzemaDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Shwetha C MuraliDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Katherine M MunsonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8413-6498
Carl BakerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Melanie SorensenDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Alexandra M LewisDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Urvashi SurtiDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Jennifer L GertonStowers Institute for Medical Research, Kansas City, MO, USA.ORCID http://orcid.org/0000-0003-0743-3637
Vladimir LarionovDevelopmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA.
Mario VenturaDepartment of Biology, University of Bari, Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0001-7762-8777
Karen H MigaCenter for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID http://orcid.org/0000-0002-3670-4507
Adam M PhillippyGenome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2983-8934
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA. eee@gs.washington.edu.ORCID http://orcid.org/0000-0002-8246-4014
University of Washington · USNational Institutes of Health · USHoward Hughes Medical Institute · USJames S. McDonnell Foundation · USNational Cancer Institute · USStowers Institute for Medical Research · USSt Petersburg University · RUUniversity of Bari Aldo Moro · ITUniversity of California San Diego · USUniversity of California, Santa Cruz · USUniversity of Pittsburgh · US
Funding
Study of hereditary prostate cancer and human artificial chromosomesZIABC010413 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LARIONOV, VLADIMIR · 2009 to 2025
$31.5MINTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2MELSI Administrative Supplement - Center for Human Reference Genome DiversityU01HG010971 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI EICHLER, EVAN, JARVIS, ERICH D · 2019 to 2023
$18.4MSingle-molecule sequence assembly and analysisZIAHG200398 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PHILLIPPY, ADAM · 2016 to 2025
$15.9MSequence and Assembly of Segmental DuplicationsR01HG002385 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2001 to 2026
$13.3MUW Center for Translational Muscle Research (Overall Application)P30AR074990 · NIAMS · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis, DANIEL RAFTERY · 2019 to 2026
$7.5MSequence-resolved structural variation of human genomesR01HG010169 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2018 to 2026
$4.5MTelomere-to-telomere assemblies of human genomesR01HG011274 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Karen Hayden Miga · 2020 to 2026
$4.5MUniversity of Washington PhD Training in Big Data for Genomics and NeuroscienceT32LM012419 · NLM · UNIVERSITY OF WASHINGTON · PI DANIEL, THOMAS L., FAIRHALL, ADRIENNE L · 2016 to 2019
$1.1MIMPROVING THROUGHPUT OF LONG READS WITH HIGH CONSENSUS BASE ACCURACY TO RESOLVE REPETITIVE DNASR21HG010548 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MIGA, KAREN HAYDEN · 2019 to 2020
$612kThe fitness effects of de novo structural variantsK99HG011041 · NHGRI · UNIVERSITY OF WASHINGTON · PI HSIEH, PINGHSUN · 2020 to 2021
$264kCentromere Sequence, Variation, and FunctionF32GM134558 · NIGMS · UNIVERSITY OF WASHINGTON · PI LOGSDON, GLENNIS AMELIA · 2019 to 2021
$195kHoward Hughes Medical InstituteNHGRI NIH HHS K99 HG011041NHGRI NIH HHS R01 HG002385NHGRI NIH HHS R01 HG010169NHGRI NIH HHS R01 HG011274NHGRI NIH HHS R21 HG010548NHGRI NIH HHS T32 HG000035NHGRI NIH HHS U01 HG010971NIAMS NIH HHS P30 AR074990NIGMS NIH HHS F32 GM134558NLM NIH HHS T32 LM012419
Abstract
The complete assembly of each human chromosome is essential for understanding human biology and evolution
Indexed as
Evolution, MolecularAnimalsCell LineCentromereChromosomes, Human, Pair 8DNA MethylationDNA, SatelliteEpigenesis, GeneticFemaleHumansMacaca mulattaMaleMinisatellite RepeatsPan troglodytesPhylogenyPongo abeliiDNA, Satellite
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.