Evidence map›Paper›PMID 33828265›Full record

ArticleInternational journal of impotence research2022

Trends in treatment of Peyronie's disease in adult men in the United States from 2008 to 2017-results from an encounter and claims database.

Odinachi I Moghalu, Rupam Das, Joshua Horns, Alexander Campbell, James M Hotaling, Alexander W Pastuszak

Open access · greenAbstract read
In one paragraph

Article in International journal of impotence research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Odinachi I MoghaluDepartment of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America. odinachi.moghalu@hsc.utah.edu.ORCID http://orcid.org/0000-0002-9377-4114
Rupam DasDepartment of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.
Joshua HornsDepartment of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.
Alexander CampbellDepartment of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.ORCID http://orcid.org/0000-0002-8697-1531
James M HotalingDepartment of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.
Alexander W PastuszakDepartment of Surgery, Division of Urology, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.
University of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Characterization of the Role of NELL1 in the Predisposition to Peyronie's and Dupuytren's Diseases.K08DK115835 · NIDDK · UNIVERSITY OF UTAH · PI PASTUSZAK, ALEXANDER WOJCIECH · 2018 to 2020
$490k
NCATS NIH HHS UL1 TR002538NIDDK NIH HHS K08 DK115835
6 · The paper itself

Abstract

Treatments for Peyronie's Disease (PD) include oral medications, intralesional injections, and surgery. Collagenase Clostridium histolyticum (CCh) is the only FDA-approved treatment for PD. We sought to examine current trends in treatment of PD across the United States. Using data in the MarketScan Database, we conducted a retrospective study of men with PD in the United States. Cases were identified by ICD-9 and 10 codes, and treatments were identified using NDC and CPT codes. Treatment rates were analyzed using a linear regression model, and a Cox proportional hazard function test was performed for time-to-treatment analysis. About 27.8% of men with PD were treated within a year of diagnosis. The annual treatment rate increased from 23.2 to 35.4%, and intralesional injection was the most used treatment. Over the study period, the percentage of men receiving treatment with oral medication increased from 0.66 to 20.5%, while the use of intralesional injection and surgery decreased. Increased odds of treatment were observed in men 45-54 years (odds ratio [OR] 1.35; 95% confidence interval [CI], 1.21-1.50; p = 0) and in the southern region (OR 1.48; 95% CI, 1.39-1.56; p = 0). Trends in treatment of PD have changed over time. Intralesional injection remains the most used treatment option for men with PD.

Indexed as

Penile IndurationAdultHumansMaleMicrobial CollagenasePenisRetrospective StudiesTreatment OutcomeUnited StatesMicrobial Collagenase

Identifiers

PMID33828265
PMCPMC8494877
OpenAlexW3149706253

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.