Trial reportBritish journal of cancer2021
The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO).
Trial report in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02748811 (Effect of Geriatric Intervention in Frail Elderly Patients Receiving Chemotherapy for Colorectal Cancer), which is not on this map. Cited by 88 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Geriatric Intervention in Frail Elderly Patients Receiving Chemotherapy for Colorectal Cancer
Who cites it
88 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness of exercise interventions on functional outcomes in frail adults with a previous or current diagnosis of cancer: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2026Pooled it
- Predictive value of the Cancer and Aging Research Group Score for chemotherapy toxicities in older adults with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Guideline
- Frailty and long-term survival of patients with colorectal cancer: a meta-analysis.Aging clinical and experimental research · 2022Pooled it
- Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer.Journal of the American Geriatrics Society · 2025Trial
- Concurrent nimotuzumab and intensity-modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma.Cancer science · 2024Trial
- Geriatric assessment with management for older patients with cancer receiving radiotherapy: a cluster-randomised controlled pilot study.BMC medicine · 2024Trial
- Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies.Haematologica · 2022Trial
- Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study.Lancet (London, England) · 2021Trial
- Turkish Cross-Cultural Adaptation of the BRIEF-MPI in Older Adults with Cancer: Convergent and Discriminative Validity Compared with the G8 and Clinical Frailty Scale.Healthcare (Basel, Switzerland) · 2026Article
- Integration of geriatric assessment-guided care plan modifications and interventions into clinical paths of older adults with cancer (GORILLA): a feasibility approach.European geriatric medicine · 2026Article
- Article
- Decision making and outcomes in colorectal cancer and frailty: the DeCaF study.Annals of the Royal College of Surgeons of England · 2026Article
- Personalizing cancer care for older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Method to engage invested partners to co-create feasible and sustainable approaches to design and implement cancer prevention and control tools.Research involvement and engagement · 2026Article
- Temporal change in skeletal muscle index as a predictor of recurrence for patients with locally advanced colorectal malignancy: a retrospective cohort study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- A Scoping Review on Exercise Interventions During Adjuvant Chemotherapy or Radiotherapy for Cancer.Cureus · 2026Review
- Review
- High prevalence of frailty identified with G8, compared with clinical frailty scale, in older patients with suspected lung cancer.BMC geriatrics · 2026Article
- Cost implications of early treatment discontinuation in cancer: a real-world data analysis.The oncologist · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder patients with colorectal cancer (CRC) experience chemotherapy dose reductions or discontinuation. Comprehensive geriatric assessment (CGA) predicts survival and chemotherapy completion in patients with cancer, but the benefit of geriatric interventions remains unexplored.
methodsThe GERICO study is a randomised Phase 3 trial including patients ≥70 years receiving adjuvant or first-line palliative chemotherapy for CRC. Vulnerable patients (G8 questionnaire ≤14 points) were randomised 1:1 to CGA-based interventions or standard care, along with guideline-based chemotherapy. The primary outcome was chemotherapy completion without dose reductions or delays. Secondary outcomes were toxicity, survival and quality of life (QoL).
resultsOf 142 patients, 58% received adjuvant and 42% received first-line palliative chemotherapy. Interventions included medication changes (62%), nutritional therapy (51%) and physiotherapy (39%). More interventional patients completed scheduled chemotherapy compared with controls (45% vs. 28%, P = 0.0366). Severe toxicity occurred in 39% of controls and 28% of interventional patients (P = 0.156). QoL improved in interventional patients compared with controls with the decreased burden of illness (P = 0.048) and improved mobility (P = 0.008).
conclusionGeriatric interventions compared with standard care increased the number of older, vulnerable patients with CRC completing adjuvant chemotherapy, and may improve the burden of illness and mobility.
trial registrationClinicalTrials.gov ID: NCT02748811.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.