ArticleEuropean journal of clinical nutrition2021
Effects of selenium on coronary artery disease, type 2 diabetes and their risk factors: a Mendelian randomization study.
Article in European journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Perspective on health and ecological risk assessments of potentially toxic metal(loid)s using aquatic biodiversity as biomonitoring indicators.Toxicology reports · 2025Review
- Trace elements and risk of diabetes-related vascular complications: results from the EPIC-Potsdam cohort study.Cardiovascular diabetology · 2025Article
- Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults.Nutrition & diabetes · 2025Article
- Unraveling the Link: Mendelian Randomization Reveals Causal Relationship Between Selenium and Metabolic Syndrome.Biological trace element research · 2025Article
- Association of Blood Selenium Levels with Diabetes and Heart Failure in American General Adults: a Cross-sectional Study of NHANES 2011-2020 pre.Biological trace element research · 2024Article
- Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.European journal of epidemiology · 2024Article
- The causal effects between selenium levels and the brain cortical structure: A two-sample Mendelian randomization study.Brain and behavior · 2023Article
- Article
- Genetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study.Kidney international reports · 2023Article
- Increased selenium and decreased iron levels in relation to risk of coronary artery disease in patients with diabetes.Frontiers in nutrition · 2023Article
- Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study.Redox biology · 2022Article
- Long-term association of serum selenium levels and the diabetes risk: Findings from a case-control study nested in the prospective Jinchang Cohort.The Science of the total environment · 2022Article
- Selenium and cancer risk: Wide-angled Mendelian randomization analysis.International journal of cancer · 2022Article
- Diet-Derived Circulating Antioxidants and Risk of Stroke: A Mendelian Randomization Study.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of selenium on coronary artery disease (CAD) and type 2 diabetes (T2D) remains unclear with inconsistent results from observational studies and randomized controlled trials. We used Mendelian randomization to obtain unconfounded estimates of the effect of selenium on CAD, T2D, lipids and glycemic traits.
methodsWe applied genetic variants strongly (P < 5 × 10
resultsGenetically predicted selenium was associated with higher T2D (OR 1.27, 95% CI 1.07-1.50, P = 0.006). There was little evidence of an association with CAD. Genetically predicted selenium was associated with lower low-density lipoprotein (LDL) cholesterol, lower high-density lipoprotein (HDL) cholesterol, higher fasting insulin and higher homeostasis model assessment of insulin resistance. These results were not robust to all sensitivity analyses. No associations with triglycerides, fasting glucose or homeostasis model assessment of β-cell function were evident.
conclusionsOur study suggests selenium may increase the risk of T2D, possibly through insulin resistance rather than pancreatic beta cell function, but may reduce lipids. We found little evidence of an association with CAD, although an inverse association cannot be definitively excluded. The effect of selenium on these outcomes warrants further investigation.
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