ArticleProceedings of the National Academy of Sciences of the United States of America2021
The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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Who cites it
69 citing papers in PubMed, 127 citations in OpenAlex.
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- tBid-Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Streptozotocin induced hyperglycemia in the axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Evolutionarily informed gene sets reveal conserved and lineage-modified transcriptional programs during vertebrate forebrain evolution.bioRxiv : the preprint server for biology · 2026Article
- Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Divergent stem cell mechanisms govern the primary body axis and appendage regeneration in the axolotl.Science advances · 2026Article
- Dorsoventral-mediatedeLife · 2026Article
- MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes.Genome research · 2026Article
- Spatial Chromatin Organization Across the Cell Cycle: Insights from Auxin-Inducible Protein Depletion.Cells · 2025Review
- Compact genomic architecture of the axolotl MHC region: setting the record straight.Immunogenetics · 2025Article
- The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians.iScience · 2025Article
- The first complete assembly for a lungless urodelan with a "miniaturized" genome, the Northern Dusky Salamander (Plethodontidae: Desmognathus fuscus).G3 (Bethesda, Md.) · 2025Article
- Two Melanthiaceae genomes with dramatic size difference provide insights into giant genome evolution and maintenance.Nature plants · 2025Article
- Optimized toolkit for the manipulation of immortalized axolotl fibroblasts.Methods (San Diego, Calif.) · 2025Article
- The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes.Genome biology · 2025Article
- Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration.Nature communications · 2025Article
- Article
- Neural regulation of H3K27me3 during the induction of patterning competency in regenerating Axolotl limb cells.Communications biology · 2025Article
- Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration.Cell genomics · 2025Article
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Vertebrates harbor recognizably orthologous gene complements but vary 100-fold in genome size. How chromosomal organization scales with genome expansion is unclear, and how acute changes in gene regulation, as during axolotl limb regeneration, occur in the context of a vast genome has remained a riddle. Here, we describe the chromosome-scale assembly of the giant, 32 Gb axolotl genome. Hi-C contact data revealed the scaling properties of interphase and mitotic chromosome organization. Analysis of the assembly yielded understanding of the evolution of large, syntenic multigene clusters, including the Major Histocompatibility Complex (MHC) and the functional regulatory landscape of the Fibroblast Growth Factor 8 (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.