ArticleImplementation science : IS2021
The FRAME-IS: a framework for documenting modifications to implementation strategies in healthcare.
Article in Implementation science : IS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 298 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Choose to Move (CTM): Implementation and Impact Evaluation of an Adapted Health-Promoting Program for Equity-Deserving Older Adults
Provincial Scale-up of Choose to Move: Implementation and Impact Evaluation of an Adapted Health-Promoting Program for Equity-Deserving Older Adults
Leveraging Project ECHO for Improved Cervical Cancer Screening in Ethiopia: An Implementation Study of Integrated HPV Selfsampling in HIV Care Centers
Who cites it
298 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Implementation science frameworks and strategies to promote adoption of and adherence to oncology clinical practice guidelines in low- and middle-income countries: a scoping review.BMC global and public health · 2026Pooled it
- Do time management interventions support wellbeing in the workplace? A systematic review.Applied psychology. Health and well-being · 2026Pooled it
- Integrating Implementation Science in Interpersonal Violence Research and Practice: A Systematic Review of Barriers and Facilitators of Implementation.Trauma, violence & abuse · 2026Pooled it
- Methods used to design audit and feedback interventions to change clinical practice: a scoping review.Frontiers in health services · 2026Pooled it
- How well are implementation strategies and target healthcare professional behaviors reported? A secondary analysis of 204 implementation trials using the TIDieR checklist and AACTT framework.Implementation science : IS · 2025Pooled it
- Parenting Interventions During the COVID-19 Pandemic: A Systematic Review of the Rationales, Process, Feasibility, Acceptability, and Impacts of Adaptation.Trauma, violence & abuse · 2024Pooled it
- A systematic review of experimentally tested implementation strategies across health and human service settings: evidence from 2010-2022.Implementation science : IS · 2024Pooled it
- Applying Implementation Science Methods to Prospectively Track the Adaptation of an Evidence-Based Deprescribing Intervention for Use in a New Health System and Country.The Permanente journal · 2026Trial
- Trial
- A comparative effectiveness trial for universal psychosocial screening with the Psychosocial Assessment Tool (PAT) across 18 childhood cancer programs in the United States: adoption, penetration, and health equity.Implementation science : IS · 2026Trial
- Modifying implementation strategies for integration of screening and management of mental disorders, including substance use disorders into other NCD care in Faridabad, Haryana as part of ICMR-MINDS project.Frontiers in public health · 2026Trial
- Trial
- Implementation outcomes of a symptom management intervention in ambulatory oncology practices evaluated using a cluster randomized stepped-wedge trial design.Implementation science : IS · 2025Trial
- Collaborative tailoring of the Reach Out, Stay Strong Essentials (ROSE) program for pregnant veterans in the U.S. Veterans Health Administration: a qualitative case study of contextual conditions and adaptations.BMC health services research · 2025Trial
- Trial
- A cross-sectional study assessing modifications to the delivery of a multi-component implementation strategy (the Get Outside, Get Active program) to improve child physical activity in early childhood education and care services.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025Trial
- Task-sharing to promote caregiver mental health, positive parenting practices, and violence prevention in vulnerable families in Sierra Leone: a pilot feasibility study.BMC psychiatry · 2024Trial
- Tracking modifications to implementation strategies: a case study from SNaP - a hybrid type III randomized controlled trial to scale up integrated systems navigation and psychosocial counseling for PWID with HIV in Vietnam.BMC medical research methodology · 2024Trial
- Application of the FRAME-IS to a multifaceted implementation strategy.BMC health services research · 2024Trial
- Design and method considerations for equity-centered implementation science and practice: A PEDALs approach.Global health research and policy · 2026Article
238 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundImplementation strategies are necessary to ensure that evidence-based practices are successfully incorporated into routine clinical practice. Such strategies, however, are frequently modified to fit local populations, settings, and contexts. While such modifications can be crucial to implementation success, the literature on documenting and evaluating them is virtually nonexistent. In this paper, we therefore describe the development of a new framework for documenting modifications to implementation strategies. DISCUSSION: We employed a multifaceted approach to developing the Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies (FRAME-IS), incorporating multiple stakeholder perspectives. Development steps included presentations of initial versions of the FRAME-IS to solicit structured feedback from individual implementation scientists ("think-aloud" exercises) and larger, international groups of researchers. The FRAME-IS includes core and supplementary modules to document modifications to implementation strategies: what is modified, the nature of the modification (including the relationship to core elements or functions), the primary goal and rationale for the modification, timing of the modification, participants in the modification decision-making process, and how widespread the modification is. We provide an example of application of the FRAME-IS to an implementation project and provide guidance on how it may be used in future work.
conclusionIncreasing attention is being given to modifications to evidence-based practices, but little work has investigated modifications to the implementation strategies used to implement such practices. To fill this gap, the FRAME-IS is meant to be a flexible, practical tool for documenting modifications to implementation strategies. Its use may help illuminate the pivotal processes and mechanisms by which implementation strategies exert their effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.