ArticleActa neuropathologica communications2021
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.
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Article in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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110citing papers in PubMed, 3 pooled it
17.1field-weighted citation impact, top 1% of its field
What it found
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Who cites it
110 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Cerebrospinal fluid biomarkers for diagnosis of Parkinson's disease: a systematic review and network meta-analysis.Journal of neurology · 2025Pooled it
- Biofluid Detection of Pathological α-Synuclein in the Prodromal Phase of Synucleinopathies.Journal of Parkinson's disease · 2024Pooled it
- Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies.Frontiers in aging neuroscience · 2022Pooled it
- Review
- Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications.iScience · 2026Article
- Signal-Analytics Modeling of Fluorescence Time-to-Detection forACS omega · 2026Article
- Deep learning-based MRI analysis reveals Lewy body co-pathology accelerates brain aging in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Enrichment and amplification of secreted α-synuclein from cellular model and saliva of patients with synucleinopathies.Biophysics reports · 2026Article
- A Systematic Comparison of Alpha-Synuclein Seed Amplification Assays for Increasing Reproducibility.Annals of clinical and translational neurology · 2026Review
- Detecting the seeds of Parkinson's disease: the evolution of α‑synuclein seed amplification assay as a clinical biomarker.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Seed Amplification Assays for Parkinson's Disease: A Review of α-Synuclein Assays in Body Fluids and Tissues.Journal of neurochemistry · 2026Review
- PET imaging of alpha-synuclein: from radiotracer design through in vitro and in vivo translation.European journal of nuclear medicine and molecular imaging · 2026Review
- Biological classification of memory clinic patients.Brain : a journal of neurology · 2026Article
- Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.Neurology · 2026Article
- Biochemical signatures of skin α-synuclein in synucleinopathies revealed by RT-QuIC assay end-product analysis.Acta neuropathologica · 2026Article
- When Proteins Go MAD-Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection.Molecular neurobiology · 2026Review
- Alpha-synuclein seeding activity in postmortem tissues from patients with diffuse and isolated Lewy bodies.Acta neuropathologica communications · 2026Article
- α-Synuclein Real-Time Quaking-Induced Conversion Assay as a Biomarker for Parkinson's Disease: Clinical Implications and Perspectives.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Microfluidic platform for understanding Parkinson's disease and α-synuclein conformation.Translational neurodegeneration · 2025Review
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Connor BargarDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Wen WangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Steven A GunzlerDepartment of Neurology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Alexandra LeFevreUniversity of Maryland Brain and Tissue Bank, Baltimore, MD, 21201, USA.
Zerui WangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Alan J LernerDepartment of Neurology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Neena SinghDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Curtis TatsuokaDepartment of Neurology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Brian ApplebyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Xiongwei ZhuDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Rong XuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Vahram HaroutunianDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Wen-Quan ZouDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. wxz6@case.edu.
Jiyan MaVan Andel Institute, Grand Rapids, MI, 49503, USA. Jiyanma333@gmail.com.
Shu G ChenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. shu.chen@case.edu.ORCID 0000-0001-7180-3001
University Hospitals of Cleveland · USUniversity School · USCase Western Reserve University · USIcahn School of Medicine at Mount Sinai · USUniversity of Maryland, Baltimore · USVan Andel Institute · US
Funding
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MPeripheral Tissue Biomarker for Premorten Diagnosis of Lewy Body DementiaR01NS118760 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, SHU G., KRAUS, ALLISON L · 2020 to 2025
$7.4MAssessing skin biomarkers for preclinical diagnosis of PD and non-PD ParkinsonismU01NS112010 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, SHU G., GUNZLER, STEVEN A. · 2019 to 2023
$3.7MCombine computational prediction, network analysis and genetic screening in C elegans to uncover neurodegenerative causes in Alzheimer's DiseaseR01AG061388 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, SHU G., XU, RONG · 2018 to 2022
$3.4MRole of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9MAn Integrated Reverse Engineering Approach Toward Rapid drug Re positioning for Alzheimer's DiseaseR01AG057557 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XU, RONG · 2017 to 2021
$2.8MRepositioning of Clinically Approved Drugs toward the Prevention and Risk Evaluation of Early Cataract ProgressionR01EY029297 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI MONNIER, VINCENT M, XU, RONG · 2019 to 2021
$2.0MConstruct large-scale phenomes of disease and drugs and develop data-driven systems approaches to understand genetic links between Alzheimer's disease and Neuropsychiatric symptomsR56AG062272 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XU, RONG · 2018 to 2019
$1.6MNIA NIH HHS R01 AG061388NINDS NIH HHS R01 NS118760NINDS NIH HHS U01 NS112010
Abstract
Definitive diagnosis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) relies on postmortem finding of disease-associated alpha-synuclein (αSyn
Indexed as
AgedAged, 80 and overalpha-SynucleinFemaleHigh-Throughput Screening AssaysHumansLewy Body DiseaseMaleMiddle AgedParkinson DiseaseSensitivity and Specificityalpha-SynucleinAlpha-synucleinBiomarkerBiospecimensCerebrospinal fluidColonDementia with Lewy bodiesParkinson’s diseaseRT-QuICSalivary glandSkin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.