ArticleAlzheimer's research & therapy2021
Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults.
Article in Alzheimer's research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies.British journal of sports medicine · 2022Pooled it
- Multimodal Retinal Imaging for the Detection of Early Alzheimer's Disease: Combining Biochemical, Structural, and Vascular Biomarkers.Bioengineering (Basel, Switzerland) · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Minor neuropsychological deficits and stage 2 of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Prediction of cognitive test scores: a comparison of brain structure, health, demographic, and cognitive data across adulthood.GeroScience · 2026Article
- The electrophysiological basis of resting-state fMRI hyperconnectivity in early Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Early aperiodic EEG changes in preclinical and prodromal Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- The prognostic potential of circulating BDNF levels and its polymorphisms in age-related cognitive impairment and neurodegeneration.Frontiers in aging neuroscience · 2026Review
- Pulsatility index is a prognostic marker of cognitive outcome in patients with transient ischemic attack and mild acute stroke.Cerebral circulation - cognition and behavior · 2026Article
- Technology Activities and Cognitive Trajectories Among Community-Dwelling Older Adults: National Health and Aging Trends Study.JMIR aging · 2025Article
- Changes in cognitive functioning and quality of life after relocation to a nursing home: a prospective longitudinal study of Swiss nursing home residents.European journal of ageing · 2025Article
- Understanding the cognitive factors which contribute to individual differences in financial capacity in aging.Scientific reports · 2025Article
- Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers.Molecular neurodegeneration · 2025Review
- Plasma vesicle-associated membrane protein 2 and glial fibrillary acidic protein associate with synaptic density in older adults without dementia.Brain communications · 2025Article
- Valence as principal dimension of the semantic space in primary progressive aphasia semantic variant.Brain communications · 2025Article
- EEG-based graph network analysis in relation to regional tau in asymptomatic Alzheimer's disease.Brain communications · 2025Article
- Development and Validation of a Vocabulary Measure in the Mobile Toolbox.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Impact of care-recipient relationship type on quality of life in caregivers of older adults with dementia over time.Age and ageing · 2024Article
- Disentangling Accelerated Cognitive Decline from the Normal Aging Process and Unraveling Its Genetic Components: A Neuroimaging-Based Deep Learning Approach.Journal of Alzheimer's disease : JAD · 2024Article
- Characterizing the clinical heterogeneity of early symptomatic Alzheimer's disease: a data-driven machine learning approach.Frontiers in aging neuroscience · 2024Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe examined in cognitively intact older adults the relative weight of cognitive, genetic, structural and amyloid brain imaging variables for predicting cognitive change over a 4-year time course.
methodsOne hundred-eighty community-recruited cognitively intact older adults (mean age 68 years, range 52-80 years, 81 women) belonging to the Flemish Prevent Alzheimer's Disease Cohort KU Leuven (F-PACK) longitudinal observational cohort underwent a baseline evaluation consisting of detailed cognitive assessment, structural MRI and
resultsA base model of age and sex explained 18.5% of variance in episodic memory decline. This increased to 41.6% by adding baseline episodic memory scores. Adding amyloid load or volumetric measures explained only a negligible additional amount of variance (increase to 42.2%). A mediation analysis indicated that the effect of age on episodic memory scores was partly direct and partly mediated via hippocampal volume. Amyloid load did not play a significant role as mediator between age, hippocampal volume and episodic memory decline.
conclusionIn cognitively intact older adults, the strongest baseline predictor of subsequent episodic memory decline was the baseline episodic memory score. When this score was included, only very limited explanatory power was added by brain volume or amyloid load measures. The data warn against classifications that are purely biomarker-based and highlight the value of baseline cognitive performance levels in predictive models.
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