ArticleCritical care (London, England)2021
FDG-PET/CT in intensive care patients with bloodstream infection.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic value of [European journal of nuclear medicine and molecular imaging · 2026Pooled it
- EANM/SNMMI guideline/procedure standard for [European journal of nuclear medicine and molecular imaging · 2025Guideline
- 18F-Fluorodeoxyglucose Positron Emission Tomography Combined With CT in Unresolved ICU Infections: Diagnostic Yield and Clinical Consequences in a Retrospective Cohort.Critical care explorations · 2026Article
- Determinants of diagnostic yield and scan quality of [Critical care (London, England) · 2026Article
- Role of lactylation modification in regulating lytic cell death.Frontiers in oncology · 2026Review
- The diagnostic role of 2-[La Radiologia medica · 2025Article
- Total-body positron emission tomography imaging to accelerate radiotracer discovery pipelines.Pharmacological reviews · 2025Review
- [Annals of intensive care · 2025Article
- Lactate and lactylation in cancer.Signal transduction and targeted therapy · 2025Review
- Role of nuclear imaging techniques in the management of infections in critically ill patients.Intensive care medicine · 2025Article
- Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications.Frontiers in immunology · 2025Review
- Review
- Positron Emission Tomography with Computed Tomography in Evaluations of Classical Fever of Unknown Origin and Length of Hospitalization: A 10-Year Medical Record Review of a Tertiary Hospital.Infection & chemotherapy · 2023Article
- [Frontiers in medicine · 2023Review
- [Clinical and translational imaging · 2023Article
- Long Axial Field-of-View PET for Ultra-Low-Dose Imaging of Non-Hodgkin Lymphoma during Pregnancy.Diagnostics (Basel, Switzerland) · 2022Article
- EARL compliance and imaging optimisation on the Biograph Vision Quadra PET/CT using phantom and clinical data.European journal of nuclear medicine and molecular imaging · 2022Article
- Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.PloS one · 2022Article
- State of the art ofClinical and translational imaging · 2021Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI.
methodsIn this retrospective cohort study, all intensive care patients from our Dutch university medical center who had culture-proven BSI between 2010 and 2020 and underwent FDG-PET/CT to find the focus of infection were included. Diagnostic performance was calculated and logistic regression analysis was performed to evaluate the association between FDG-PET/CT outcome and C-reactive protein level (CRP), leukocyte count, duration of antibiotic treatment, duration of ICU stay, quality of FDG-PET/CT, and dependency on mechanical ventilation. In addition, the impact of FDG-PET/CT on clinical treatment was evaluated.
results30 intensive care patients with BSI were included. In 21 patients, an infection focus was found on FDG-PET/CT which led to changes in clinical management in 14 patients. FDG-PET/CT achieved a sensitivity of 90.9% and specificity of 87.5% for identifying the focus of infection. Poor quality of the FDG-PET images significantly decreased the likelihood of finding an infection focus as compared to reasonable or good image quality (OR 0.16, P = 0.034). No other variables were significantly associated with FDG-PET/CT outcome. No adverse events during the FDG-PET/CT procedure were reported.
conclusionFDG-PET/CT has a high diagnostic yield for detecting the infection focus in patients with BSI admitted to intensive care. Poor PET image quality was significantly associated with a decreased likelihood of finding the infection focus in patients with BSI. This could be improved by adequate dietary preparation and cessation of intravenous glucose and glucose-regulating drugs. Recent advances in PET/CT technology enable higher image quality with shorter imaging time and may contribute to routinely performing FDG-PET/CT in intensive care patients with BSI of unknown origin.
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