ArticleNutrition & metabolism2021
Pineapple consumption reduced cardiac oxidative stress and inflammation in high cholesterol diet-fed rats.
Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Consumption of Terminalia catappa powder: modulation of lipid metabolism, reduction of cardiovascular risk, and hepatic protection in aged Wistar rats.Biogerontology · 2026Article
- Antiobesity Potential of Selected Latin American Edible Plants: A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Review
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- Potential of Fruits to Improve Dyslipidemias: A Pilot Review.Vascular health and risk management · 2025Review
- Beneficial Effects Induced by a Proprietary Blend of a New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine in Urinary Tract Infections: Results from In Vitro and Ex Vivo Studies.Antibiotics (Basel, Switzerland) · 2024Article
- Article
- Solid-State Fermented Pineapple Peel: A Novel Food Ingredient with Antioxidant and Anti-Inflammatory Properties.Foods (Basel, Switzerland) · 2023Article
- Wax apple (Journal of traditional and complementary medicine · 2022Article
- Potential of Industrial Pineapple (Antioxidants (Basel, Switzerland) · 2021Article
- Tropical Fruits and Their Co-Products as Bioactive Compounds and Their Health Effects: A Review.Foods (Basel, Switzerland) · 2021Review
- Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action.Vascular health and risk management · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHypercholesterolemia is a major risk factor for cardiovascular disease. It has been reported that pineapple contains healthy nutrients and phytochemicals associated with antioxidant and anti-inflammatory capacities. No investigation exists concerning the effect of pineapple consumption modulating hypercholesterolemia-induced cardiac damage in high-cholesterol diet (HCD)-fed rats. This study evaluated the effect of pineapple consumption on lipid-lowering, cardiac oxidative stress and inflammation in HCD-fed rats.
methodsMale Sprague-Dawley rats were fed with HCD, in the presence and absence of Pineapple (Ananas comosus L.) cv. Pattavia powder for 8 weeks. Then, serum lipid profiles, liver and renal function tests, cardiac oxidative stress and pro-inflammatory cytokines were determined.
resultsDaily pineapple consumption reduced weight gain, serum lipid profiles, atherogenic coefficient (AC), cardiac risk ratio (CRR), and liver enzyme activity, without causing renal dysfunction. Pineapple consumption also restores cardiac protein carbonyl (cPC) content, reduces cardiac malondialdehyde (MDA), cardiac pro-inflammation cytokine IL-6 and IL-1β levels.
conclusionPineapple possesses antioxidant and lipid-lowering properties and daily consumption alleviates hypercholesterolemia-induced cardiac lipid peroxidation and pro-inflammation elevation in an in vivo model. This study demonstrates that pineapple is a potential candidate for cardioprotection against hypercholesterolemia.
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