Evidence map›Paper›PMID 33827609›Full record

ArticleJournal of translational medicine2021

The "Great Debate" at Immunotherapy Bridge 2020, December 3rd, 2020.

Paolo A Ascierto, Joshua Brody, Lisa H Butterfield, Olivera J Finn, John Goldberg, Francesco Perrone, Ryan J Sullivan, Bernard A Fox, Patrick Hwu, Igor Puzanov

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Paolo A AsciertoDepartment of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.ORCID 0000-0002-8322-475X
Joshua BrodyLymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lisa H ButterfieldParker Institute for Cancer Immunotherapy, Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Olivera J FinnDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
John GoldbergClinical Development, Oncorus, Cambridge, MA, USA.
Francesco PerroneUnit of Clinical Trial, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
Ryan J SullivanHematology-Oncology Dept, Massachusetts General Hospital, Boston, MA, USA.
Bernard A FoxEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Cancer Institute, Portland, OR, USA.
Patrick HwuMoffitt Cancer Center, Tampa, FL, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITIcahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · USMoffitt Cancer Center · USOncor (United States) · USProvidence Portland Medical Center · USRoswell Park Comprehensive Cancer Center · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

Immunoprevention and immunosurveillance of human non-viral cancersR35CA210039 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINN, OLIVERA J · 2016 to 2022
$6.0M
NCI NIH HHS R35 CA210039
6 · The paper itself

Abstract

As part of the 2020 Immunotherapy Bridge virtual congress (December 2nd-3rd, Italy), the Great Debate session featured counterpoint views from leading experts on three clinical questions in immunotherapy today. The first of these was whether antitumoral vaccination is still a treatment option. The second topic debated whether anti-programmed death (PD)-1/PD-ligand (L)1 blockade should be the backbone for immunotherapy combination. Finally, the use of innovative study designs and surrogate endpoints was considered from both an academic and industry perspective. For each topic, two experts presented the argument and counter-argument in support of two different points of view. As with previous Bridge congresses, the debates were assigned by meeting Chairs and positions taken by experts during the debates may not have necessarily reflected their respective personal view. The views summarised in this article are based on available evidence but may reflect personal interpretation of these data, clinical experience and subjective opinion of the speaker.

Indexed as

ImmunotherapyItalyCancer vaccineCheckpoint inhibitorsClinical trialsImmunotherapyNivolumabOverall survivalPembrolizumabProgression-free survival

Identifiers

PMID33827609
PMCPMC8025454
OpenAlexW3140894956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.