ArticleBMC oral health2021
Analysis of oral microbial dysbiosis associated with early childhood caries.
Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Pediatric Dental Education in China: Current Status, Challenges, and Pathways to Improvement-A Narrative Review.Dentistry journal · 2026Review
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- From Caries to Periodontal Breakdown: A Biological and Clinical Continuum Linking Cariology, Operative Dentistry, Endodontics, and Periodontology.Dentistry journal · 2026Review
- Effects of Oral Probiotics onDentistry journal · 2026Review
- Effects of cigarette smoking on the oral microbiome in adolescents.Scientific reports · 2026Article
- Effects of Antiseptic Formulations on Oral Microbiota and Related Systemic Diseases: A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- Supragingival plaque microbiota and caries risk factors among children with mixed dentition.BMC oral health · 2025Article
- Comparative evaluation of oral microbiologic profile in children with Type 1 Diabetes Mellitus versus healthy controls and its relation to oral health status.BMC oral health · 2025Article
- Impact of Marital Status, Education, and Family Size on Parental Behaviors Toward Early Childhood Caries in Romania.Dentistry journal · 2025Article
- Imbalance of oral microbiome homeostasis: the relationship between microbiota and the occurrence of dental caries.BMC microbiology · 2025Article
- Exploring Competitive Relationship BetweenMicroorganisms · 2025Article
- Anesthetics change the oral microbial composition of children and increase the abundance of the genusTranslational pediatrics · 2024Article
- Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment-The Role of Ceragenins in the Development of New Therapeutic Methods.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Oral microbiota in preschoolers with rampant caries: a matched case-control study.Applied microbiology and biotechnology · 2024Article
- Highly accurate measurement of the relative abundance of oral pathogenic bacteria using colony-forming unit-based qPCR.Journal of periodontal & implant science · 2024Article
- Comparison of the Effect of Bioglass, Chitosan, and SDF Compounds on Remineralization of Primary Caries Lesions in Primary Teeth: AnJournal of dentistry (Shiraz, Iran) · 2024Article
- Antibacterial coating of orthodontic elastomeric ligatures with silver and bismuth nanofilms by magnetron sputtering: A feasibility study.Clinical and experimental dental research · 2024Article
- Ancient Genomes From Bronze Age Remains Reveal Deep Diversity and Recent Adaptive Episodes for Human Oral Pathobionts.Molecular biology and evolution · 2024Article
- Comparison of the main pathogenic microorganisms of various common oral diseases in children and adults.Pediatric discovery · 2023Article
- Modified Lactoperoxidase System as a Promising Anticaries Agent: In Vitro Studies onInternational journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background"Core microbes" play a key role in the development of caries and lead to microbial disorders. Our goal was to detect the core microbes associated with the microbiota imbalance in early childhood caries (ECC).
methodsFifteen caries-free children and fifteen high-caries (DMFT ≥ 10) children aged 4-6 years old were recruited according to the diagnostic criteria of caries suggested by the WHO. The 16S rRNA genes from samples of plaque in saliva were amplified by PCR, and the PCR products were sequenced by the Illumina Miseq platform. The sequencing results were analyzed by professional software to determine the composition and structure of the saliva microorganisms.
resultsThere were statistically significant differences between the groups regarding the relative abundance of Streptococcus mutans (Wilcoxon rank-sum test, P < 0.05). No significant difference was found between the groups regarding other species or functional genes.
conclusionS. mutans, together with other pathogens, may play a prominent role and act as "core microbes" in the occurrence and development of early childhood caries.
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